Human NOP2 protein (Recombinant) (N-His) (STJP016260)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human NOP2-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for further information. |
Target Information
| Gene Symbol | NOP2 |
| Gene ID | 4839 |
| Uniprot ID | NOP2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Glu217-Ser588 |
Additional Info
| Function | S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA. Required for efficient rRNA processing and 60S ribosomal subunit biogenesis. Regulates pre-rRNA processing through non-catalytic complex formation with box C/D snoRNAs and facilitates the recruitment of U3 and U8 snoRNAs to pre-90S ribosomal particles and their stable assembly into snoRNP complexes. May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation. |
| Protein Name | 28s RrnaCytosine(4447-C(5-MethyltransferaseNucleolar Protein 1Nucleolar Protein 2 HomologProliferating-Cell Nucleolar Antigen P120Proliferation-Associated Nucleolar Protein P120 |
| Database Links | Reactome: R-HSA-6790901Reactome: R-HSA-8869496 |
| Cellular Localisation | NucleusNucleolusLocalizes Predominantly In The Nucleolus And To A Smaller Extent In The Nucleus |
| Alternative Protein Names | 28s Rrna proteinCytosine(4447-C(5-Methyltransferase proteinNucleolar Protein 1 proteinNucleolar Protein 2 Homolog proteinProliferating-Cell Nucleolar Antigen P120 proteinProliferation-Associated Nucleolar Protein P120 proteinNOP2 proteinNOL1 proteinNSUN1 protein |
Information sourced from Uniprot.org