Human NOP2 protein (Recombinant) (N-His) (STJP016260)

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STJP016260
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Short Description :Recombinant-Human NOP2-N-His protein was developed from e.coli for the region N-His. For use in research applications.
Applications:ELISA/Immunogen/SDS-PAGE/WB
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Dilution Range:Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Formulation:Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction:Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin:Please contact us for further information.
Gene Symbol:NOP2
Gene ID:4839
Uniprot ID:NOP2_HUMAN
Immunogen:Homo sapiens (Human)
Immunogen Region:Glu217-Ser588
Function S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA. Required for efficient rRNA processing and 60S ribosomal subunit biogenesis. Regulates pre-rRNA processing through non-catalytic complex formation with box C/D snoRNAs and facilitates the recruitment of U3 and U8 snoRNAs to pre-90S ribosomal particles and their stable assembly into snoRNP complexes. May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation.
Protein Name 28s Rrna
Cytosine(4447-C(5-Methyltransferase
Nucleolar Protein 1
Nucleolar Protein 2 Homolog
Proliferating-Cell Nucleolar Antigen P120
Proliferation-Associated Nucleolar Protein P120
Database Links Reactome: R-HSA-6790901
Reactome: R-HSA-8869496
Cellular Localisation Nucleus
Nucleolus
Localizes Predominantly In The Nucleolus And To A Smaller Extent In The Nucleus
Alternative Protein Names 28s Rrna protein
Cytosine(4447-C(5-Methyltransferase protein
Nucleolar Protein 1 protein
Nucleolar Protein 2 Homolog protein
Proliferating-Cell Nucleolar Antigen P120 protein
Proliferation-Associated Nucleolar Protein P120 protein
NOP2 protein
NOL1 protein
NSUN1 protein

Information sourced from Uniprot.org