Human NEIL1 protein (Recombinant) (His-Tag) (STJP017470)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human NEIL1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 20% Glycerol, 0.1M NaCl, 1mM DTT, 0.1mM PMSF |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NEIL1 |
| Gene ID | 79661 |
| Uniprot ID | NEIL1_HUMAN |
| Accession Number | NP_078884.2 |
| Immunogen | Human |
| Immunogen Region | 1-390aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Ubiquitous. |
| Function | Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as a DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. |
| Protein Name | Endonuclease 8-Like 1Dna Glycosylase/Ap Lyase Neil1Dna-(Apurinic Or Apyrimidinic Site Lyase Neil1Endonuclease Viii-Like 1Fpg1Nei Homolog 1Neh1Nei-Like Protein 1 |
| Database Links | Reactome: R-HSA-110328Reactome: R-HSA-110329Reactome: R-HSA-5649702Reactome: R-HSA-9616334 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeNucleusChromosomeDuring MitosisAssociates With Centrosomes And Condensed Chromatin |
| Alternative Protein Names | Endonuclease 8-Like 1 proteinDna Glycosylase/Ap Lyase Neil1 proteinDna-(Apurinic Or Apyrimidinic Site Lyase Neil1 proteinEndonuclease Viii-Like 1 proteinFpg1 proteinNei Homolog 1 proteinNeh1 proteinNei-Like Protein 1 proteinNEIL1 protein |
Information sourced from Uniprot.org