Human MZB1 protein (Recombinant) (His-Tag) (STJP018729)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human MZB1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% Glycerol, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MZB1 |
| Gene ID | 51237 |
| Uniprot ID | MZB1_HUMAN |
| Accession Number | AAH09931 |
| Immunogen | Human |
| Immunogen Region | 1-97aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Widely expressed with highest levels in adult brain, small intestine and lymphoid tissues such as thymus and spleen. Expression is frequently lower in intestinal-type gastric cancer. In obese patients, more abundant in omental than in subcutaneous fat. |
| Post Translational Modifications | Forms an interchain disulfide bond with IgM monomers. |
| Function | Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity. Isoform 2 may be involved in regulation of apoptosis. Helps to diversify peripheral B-cell functions by regulating Ca(2+) stores, antibody secretion and integrin activation. Acts as a hormone-regulated adipokine/pro-inflammatory cytokine that is implicated in causing chronic inflammation, affecting cellular expansion and blunting insulin response in adipocytes. May have a role in the onset of insulin resistance. |
| Protein Name | Marginal Zone B- And B1-Cell-Specific ProteinMesenteric Estrogen-Dependent Adipose 7Meda-7Plasma Cell-Induced Resident Endoplasmic Reticulum ProteinPlasma Cell-Induced Resident Er ProteinPerp1Proapoptotic Caspase Adapter Protein |
| Database Links | |
| Cellular Localisation | Isoform 1: Endoplasmic Reticulum LumenSecretedIsoform 2: CytoplasmDiffuse Granular Localization In The Cytoplasm Surrounding The Nucleus |
| Alternative Protein Names | Marginal Zone B- And B1-Cell-Specific Protein proteinMesenteric Estrogen-Dependent Adipose 7 proteinMeda-7 proteinPlasma Cell-Induced Resident Endoplasmic Reticulum Protein proteinPlasma Cell-Induced Resident Er Protein proteinPerp1 proteinProapoptotic Caspase Adapter Protein proteinMZB1 proteinMEDA7 proteinPACAP proteinHSPC190 protein |
Information sourced from Uniprot.org