Human MYDGF protein (Recombinant) (C-His) (STJP001958)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human MYDGF Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Val32-Leu173) of human MYDGF (Accession #NP_061980.1) fused with a 6×His tag at the C-terminus.
General Information
| Short Description | Recombinant-Human MYDGF-C-His protein was developed in hek293 cells using the region Val32-Leu173. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 0.1 EU/Mu g |
Target Information
| Gene Symbol | MYDGF |
| Gene ID | 56005 |
| Uniprot ID | MYDGF_HUMAN |
| Immunogen | Recombinant Human MYDGF Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Val32-Leu173) of human MYDGF (Accession #NP_061980.1) fused with a 6×His tag at the C-terminus. |
| Immunogen Region | Val32-Leu173 |
| Immunogen Sequence | VSEPTTVAFDVRPGGVVHSF SHNVGPGDKYTCMFTYASQG GTNEQWQMSLGTSEDHQHFT CTIWRPQGKSYLYFTQFKAE VRGAEIEYAMAYSKAAFERE SDVPLKTEEFEVTKTAVAHR PGAFKAELSKLVIVAKASRT EL |
Additional Info
| Function | Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway. Involved in endothelial cell proliferation and angiogenesis. |
| Protein Name | Myeloid-Derived Growth FactorMydgf |
| Database Links | Reactome: R-HSA-381038 |
| Cellular Localisation | SecretedEndoplasmic Reticulum-Golgi Intermediate CompartmentEndoplasmic ReticulumGolgi ApparatusThe C-Terminal Rtel Motif May Provide Retention In The Endoplasmic Reticulum |
| Alternative Protein Names | Myeloid-Derived Growth Factor proteinMydgf proteinMYDGF proteinC19orf10 protein |
Information sourced from Uniprot.org