| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 0.1 EU/Mu g |
| Gene Symbol: | MYDGF |
| Gene ID: | 56005 |
| Uniprot ID: | MYDGF_HUMAN |
| Immunogen Region: | Val32-Leu173 |
| Immunogen: | Recombinant Human MYDGF Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Val32-Leu173) of human MYDGF (Accession #NP_061980.1) fused with a 6×His tag at the C-terminus. |
| Immunogen Sequence: | VSEPTTVAFDVRPGGVVHSF SHNVGPGDKYTCMFTYASQG GTNEQWQMSLGTSEDHQHFT CTIWRPQGKSYLYFTQFKAE VRGAEIEYAMAYSKAAFERE SDVPLKTEEFEVTKTAVAHR PGAFKAELSKLVIVAKASRT EL |
| Function | Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway. Involved in endothelial cell proliferation and angiogenesis. |
| Protein Name | Myeloid-Derived Growth FactorMydgf |
| Database Links | Reactome: R-HSA-381038 |
| Cellular Localisation | SecretedEndoplasmic Reticulum-Golgi Intermediate CompartmentEndoplasmic ReticulumGolgi ApparatusThe C-Terminal Rtel Motif May Provide Retention In The Endoplasmic Reticulum |
| Alternative Protein Names | Myeloid-Derived Growth Factor proteinMydgf proteinMYDGF proteinC19orf10 protein |
Information sourced from Uniprot.org
