Human MAT1A protein (Recombinant) (His-Tag) (STJP016630)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human MAT1A-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 0.1M NaCl, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MAT1A |
| Gene ID | 4143 |
| Uniprot ID | METK1_HUMAN |
| Accession Number | NP_000420.1 |
| Immunogen | Human |
| Immunogen Region | 1-395aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Expressed in liver. |
| Post Translational Modifications | S-nitrosylation of Cys-120 inactivates the enzyme. An intrachain disulfide bond can be formed. The protein structure shows that the relevant Cys residues are in a position that would permit formation of a disulfide bond. |
| Function | Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate. |
| Protein Name | S-Adenosylmethionine Synthase Isoform Type-1Adomet Synthase 1Methionine Adenosyltransferase 1Mat 1Methionine Adenosyltransferase I/IiiMat-I/Iii |
| Database Links | Reactome: R-HSA-156581Reactome: R-HSA-1614635Reactome: R-HSA-2408508Reactome: R-HSA-5579024 |
| Cellular Localisation | |
| Alternative Protein Names | S-Adenosylmethionine Synthase Isoform Type-1 proteinAdomet Synthase 1 proteinMethionine Adenosyltransferase 1 proteinMat 1 proteinMethionine Adenosyltransferase I/Iii proteinMat-I/Iii proteinMAT1A proteinAMS1 proteinMATA1 protein |
Information sourced from Uniprot.org