Human MAGEA6 protein (Recombinant) (N-His) (STJP011302)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human MAGEA6-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | MAGEA6 |
| Gene ID | 4105 |
| Uniprot ID | MAGA6_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ser96-Glu314 |
Additional Info
| Post Translational Modifications | Ubiquitinated by the DCX(DCAF12) complex specifically recognizes the diglutamate (Glu-Glu) at the C-terminus, leading to its degradation. |
| Function | Activator of ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases that acts as a repressor of autophagy. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. |
| Protein Name | Melanoma-Associated Antigen 6Cancer/Testis Antigen 1.6Ct1.6Mage-6 AntigenMage3b Antigen |
| Database Links | |
| Cellular Localisation | |
| Alternative Protein Names | Melanoma-Associated Antigen 6 proteinCancer/Testis Antigen 1.6 proteinCt1.6 proteinMage-6 Antigen proteinMage3b Antigen proteinMAGEA6 proteinMAGE6 protein |
Information sourced from Uniprot.org