Human MAGEA6 protein (Recombinant) (N-His) (STJP011302)

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STJP011302
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Short Description :Recombinant-Human MAGEA6-N-His protein was developed from e.coli for the region N-His. For use in research applications.
Applications:ELISA/Immunogen/SDS-PAGE/WB
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Dilution Range:Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Formulation:Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction:Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol:MAGEA6
Gene ID:4105
Uniprot ID:MAGA6_HUMAN
Immunogen:Homo sapiens (Human)
Immunogen Region:Ser96-Glu314
Post Translational Modifications Ubiquitinated by the DCX(DCAF12) complex specifically recognizes the diglutamate (Glu-Glu) at the C-terminus, leading to its degradation.
Function Activator of ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases that acts as a repressor of autophagy. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines.
Protein Name Melanoma-Associated Antigen 6
Cancer/Testis Antigen 1.6
Ct1.6
Mage-6 Antigen
Mage3b Antigen
Database Links
Cellular Localisation
Alternative Protein Names Melanoma-Associated Antigen 6 protein
Cancer/Testis Antigen 1.6 protein
Ct1.6 protein
Mage-6 Antigen protein
Mage3b Antigen protein
MAGEA6 protein
MAGE6 protein

Information sourced from Uniprot.org

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