| Host: |
E.coli |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: |
Lyophilised from a 0.22 Mu m filtered solution of 20mM PB, 150mM NaCl, pH 7.4/20mM PB, 150mM NaCl, pH 7.4, 50% Glycerol |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: |
< 1 EU/Mu g of the protein by LAL method. |
| Gene Symbol: |
MIF |
| Gene ID: |
4282 |
| Uniprot ID: |
MIF_HUMAN |
| Immunogen Region: |
Met1-Ala115 |
| Immunogen: |
Recombinant human Macrophage migration inhibitory factor/MIF Protein is produced by E.coli expression system. The target protein is expressed with sequence (Met1-Ala115) of human Macrophage migration inhibitory factor/MIF (Accession #NP_002406.1) fus |
| Immunogen Sequence: |
PGPPAGSPRVSSDPRADLDS AVLLTRSLLADTRQLAAQMR DKFPADGDHSLDSLPTLAMS AGTLGSLQLPGVLTRLRVDL MSYLRHVQWLRRAGGPSLKT LEPELGALQARLERLLRRLQ LLMSRLALPQAAPDQPVIPL GPPASAWGSIRAAHAILGGL HLTLDWAVRGLLLLKTRL |
| Function | Pro-inflammatory cytokine involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity. |
| Protein Name | Macrophage Migration Inhibitory FactorMifGlycosylation-Inhibiting FactorGifL-Dopachrome IsomeraseL-Dopachrome TautomerasePhenylpyruvate Tautomerase |
| Database Links | Reactome: R-HSA-202733Reactome: R-HSA-6798695Reactome: R-HSA-8950505 |
| Cellular Localisation | SecretedCytoplasmDoes Not Have A Cleavable Signal Sequence And Is Secreted Via A SpecializedNon-Classical PathwaySecreted By Macrophages Upon Stimulation By Bacterial Lipopolysaccharide (Lps)Or By MTuberculosis Antigens |
| Alternative Protein Names | Macrophage Migration Inhibitory Factor proteinMif proteinGlycosylation-Inhibiting Factor proteinGif proteinL-Dopachrome Isomerase proteinL-Dopachrome Tautomerase proteinPhenylpyruvate Tautomerase proteinMIF proteinGLIF proteinMMIF protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
