Human Macrophage migration inhibitory factor/MIF protein (Recombinant) (No tag) (STJP003061)

SKU:
STJP003061

£148.50 - £493.50
Current Stock:
Host: E.coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Formulation: Lyophilised from a 0.22 Mu m filtered solution of 20mM PB, 150mM NaCl, pH 7.4/20mM PB, 150mM NaCl, pH 7.4, 50% Glycerol
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: < 1 EU/Mu g of the protein by LAL method.
Gene Symbol: MIF
Gene ID: 4282
Uniprot ID: MIF_HUMAN
Immunogen Region: Met1-Ala115
Immunogen: Recombinant human Macrophage migration inhibitory factor/MIF Protein is produced by E.coli expression system. The target protein is expressed with sequence (Met1-Ala115) of human Macrophage migration inhibitory factor/MIF (Accession #NP_002406.1) fus
Immunogen Sequence: PGPPAGSPRVSSDPRADLDS AVLLTRSLLADTRQLAAQMR DKFPADGDHSLDSLPTLAMS AGTLGSLQLPGVLTRLRVDL MSYLRHVQWLRRAGGPSLKT LEPELGALQARLERLLRRLQ LLMSRLALPQAAPDQPVIPL GPPASAWGSIRAAHAILGGL HLTLDWAVRGLLLLKTRL
Function Pro-inflammatory cytokine involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.
Protein Name Macrophage Migration Inhibitory Factor
Mif
Glycosylation-Inhibiting Factor
Gif
L-Dopachrome Isomerase
L-Dopachrome Tautomerase
Phenylpyruvate Tautomerase
Database Links Reactome: R-HSA-202733
Reactome: R-HSA-6798695
Reactome: R-HSA-8950505
Cellular Localisation Secreted
Cytoplasm
Does Not Have A Cleavable Signal Sequence And Is Secreted Via A Specialized
Non-Classical Pathway
Secreted By Macrophages Upon Stimulation By Bacterial Lipopolysaccharide (Lps)
Or By M
Tuberculosis Antigens
Alternative Protein Names Macrophage Migration Inhibitory Factor protein
Mif protein
Glycosylation-Inhibiting Factor protein
Gif protein
L-Dopachrome Isomerase protein
L-Dopachrome Tautomerase protein
Phenylpyruvate Tautomerase protein
MIF protein
GLIF protein
MMIF protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance