Human LRSAM1/hTAL protein (Recombinant) (N-His) (STJP008495)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human LRSAM1/hTAL-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | LRSAM1 |
| Gene ID | 90678 |
| Uniprot ID | LRSM1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Asp32-Glu211 |
Additional Info
| Post Translational Modifications | Ubiquitination promoted by PHF23 leads to proteasomal degradation. |
| Function | E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos. Bacterial recognition protein that defends the cytoplasm from invasive pathogens. Localizes to several intracellular bacterial pathogens and generates the bacteria-associated ubiquitin signal leading to autophagy-mediated intracellular bacteria degradation (xenophagy). |
| Protein Name | E3 Ubiquitin-Protein Ligase Lrsam1Leucine-Rich Repeat And Sterile Alpha Motif-Containing Protein 1Ring-Type E3 Ubiquitin Transferase Lrsam1Tsg101-Associated LigaseHtal |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmDisplays A Punctuate Distribution And Localizes To A Submembranal RingLocalizes To Intracellular Bacterial Pathogens |
| Alternative Protein Names | E3 Ubiquitin-Protein Ligase Lrsam1 proteinLeucine-Rich Repeat And Sterile Alpha Motif-Containing Protein 1 proteinRing-Type E3 Ubiquitin Transferase Lrsam1 proteinTsg101-Associated Ligase proteinHtal proteinLRSAM1 proteinTAL proteinUNQ6496 proteinPRO21356 protein |
Information sourced from Uniprot.org