Name: Human LRSAM1/hTAL protein (Recombinant) (N-His) (STJP008495)
SKU: STJP008495
Availability: InStock

Human LRSAM1/hTAL protein (Recombinant) (N-His) (STJP008495)

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STJP008495

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Host:	E. coli
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description :	Recombinant-Human LRSAM1/hTAL-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.

Formulation:	Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction:	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.

Post Translational Modifications	Ubiquitination promoted by PHF23 leads to proteasomal degradation.
Function	E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos. Bacterial recognition protein that defends the cytoplasm from invasive pathogens. Localizes to several intracellular bacterial pathogens and generates the bacteria-associated ubiquitin signal leading to autophagy-mediated intracellular bacteria degradation (xenophagy).
Protein Name	E3 Ubiquitin-Protein Ligase Lrsam1 Leucine-Rich Repeat And Sterile Alpha Motif-Containing Protein 1 Ring-Type E3 Ubiquitin Transferase Lrsam1 Tsg101-Associated Ligase Htal
Database Links	Reactome: R-HSA-983168
Cellular Localisation	Cytoplasm Displays A Punctuate Distribution And Localizes To A Submembranal Ring Localizes To Intracellular Bacterial Pathogens
Alternative Protein Names	E3 Ubiquitin-Protein Ligase Lrsam1 protein Leucine-Rich Repeat And Sterile Alpha Motif-Containing Protein 1 protein Ring-Type E3 Ubiquitin Transferase Lrsam1 protein Tsg101-Associated Ligase protein Htal protein LRSAM1 protein TAL protein UNQ6496 protein PRO21356 protein

Information sourced from Uniprot.org

Model	Name	Host
STJP005172	Human COL10A1, N-His protein (Recombinant) (N-His) (STJP005172)	E. coli
STJP004723	Human WAS protein (Recombinant) (N-His) (STJP004723)	E. coli
STJP002980	Human KLHL20 protein (Recombinant) (N-His) (STJP002980)	HEK293 cells
STJP003027	Human CCL3L1 protein (Recombinant) (N-His) (STJP003027)	HEK293 cells
STJP003488	Human CFD protein (Recombinant) (N-His) (STJP003488)	E. coli

Human LRSAM1/hTAL protein (Recombinant) (N-His) (STJP008495)

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