Human LMIR1/CD300a protein (Recombinant) (C-hFc&His) (STJP001034)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human LMIR1/CD300a Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Leu 18-Gln 178 ) of human CD300A (Accession #NP_009192.2) fused with an Fc, 6×His tag at the C-terminus.
General Information
| Short Description | Recombinant-Human LMIR1/CD300a-C-hFc&His protein was developed in hek293 cells using the region Leu 18-Gln 178. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 0.1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | CD300A |
| Gene ID | 11314 |
| Uniprot ID | CLM8_HUMAN |
| Immunogen | Recombinant Human LMIR1/CD300a Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Leu 18-Gln 178 ) of human CD300A (Accession #NP_009192.2) fused with an Fc, 6×His tag at the C-terminus. |
| Immunogen Region | Leu 18-Gln 178 |
| Immunogen Sequence | LSKCRTVAGPVGGSLSVQCP YEKEHRTLNKYWCRPPQIFL CDKIVETKGSAGKRNGRVSI RDSPANLSFTVTLENLTEED AGTYWCGVDTPWLRDFHDPV VEVEVSVFPASTSMTPASIT AAKTSTITTAFPPVSSTTLF AVGATHSASIQEETEEVVNS Q |
Additional Info
| Post Translational Modifications | Phosphorylated on tyrosine. N-glycosylated. |
| Function | Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6. |
| Protein Name | Cmrf35-Like Molecule 8Clm-8Cd300 Antigen-Like Family Member ACmrf-35-H9Cmrf35-H9Cmrf35-HIrc1/Irc2Immunoglobulin Superfamily Member 12Igsf12Inhibitory Receptor Protein 60Irp60Nk Inhibitory ReceptorCd Antigen Cd300a |
| Database Links | Reactome: R-HSA-198933Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Cmrf35-Like Molecule 8 proteinClm-8 proteinCd300 Antigen-Like Family Member A proteinCmrf-35-H9 proteinCmrf35-H9 proteinCmrf35-H proteinIrc1/Irc2 proteinImmunoglobulin Superfamily Member 12 proteinIgsf12 proteinInhibitory Receptor Protein 60 proteinIrp60 proteinNk Inhibitory Receptor proteinCd Antigen Cd300a proteinCD300A proteinCMRF35H proteinIGSF12 proteinHSPC083 protein |
Information sourced from Uniprot.org