Biotinylated Human LILRB2 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Human LILRB2/CD85d/ILT4 protein (Recombinant) (C-His-Avi) {Biotin} (STJP001660)

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STJP001660
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Short Description :Recombinant-Human LILRB2/CD85d/ILT4-C-His-Avi protein was developed from hek293 and has a target region of C-His-Avi. For use in research applications.
Host:HEK293
Note:STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Conjugation:Biotin
Dilution Range:Upon receipt centrifuge vial to ensure maximal product extraction, recommended: 20sec, 5K RPM
Formulation:Lyophilised from 0.2 µm filtered PBS solution pH7.4.
Storage Instruction:The lyophilized protein is stable for at least 1 year from date of receipt at-20°C.
Endotoxin:Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg).
Gene Symbol:LILRB2
Gene ID:10288
Uniprot ID:LIRB2_HUMAN
Immunogen:DNA sequence encoding Human LILRB2/CD85d/ILT4 including a C-His-Avi tag was expressed in HEK293 Cells. The recombinant protein was then biotinylated site specific using the AVItag biotinylation technology.
Immunogen Region:Gln22-His458
Post Translational Modifications Phosphorylated on tyrosine residues. Dephosphorylated by PTPN6.
Function Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles. Involved in the down-regulation of the immune response and the development of tolerance. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M) triggering differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.
Protein Name Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2
Lir-2
Leukocyte Immunoglobulin-Like Receptor 2
Cd85 Antigen-Like Family Member D
Immunoglobulin-Like Transcript 4
Ilt-4
Monocyte/Macrophage Immunoglobulin-Like Receptor 10
Mir-10
Cd Antigen Cd85d
Database Links Reactome: R-HSA-198933
Reactome: R-HSA-6798695
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2 protein
Lir-2 protein
Leukocyte Immunoglobulin-Like Receptor 2 protein
Cd85 Antigen-Like Family Member D protein
Immunoglobulin-Like Transcript 4 protein
Ilt-4 protein
Monocyte/Macrophage Immunoglobulin-Like Receptor 10 protein
Mir-10 protein
Cd Antigen Cd85d protein
LILRB2 protein
ILT4 protein
LIR2 protein
MIR10 protein

Information sourced from Uniprot.org

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