• Biotinylated Human LILRB2 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
  • The purity of Biotinylated Human LILRB2 is greater than 95% as determined by SEC-HPLC.
  • Immobilized Anti-LILRB2 Antibody, hFc Tag at 0. 5 Mu g/ml (100 Mu l/well) on the plate. Dose response curve for Biotinylated Human LILRB2, His Tag with the EC50 of 72. 6ng/ml determined by ELISA.

Human LILRB2/CD85d/ILT4 protein (Recombinant) (C-His-Avi) {Biotin} (STJP001660)

SKU:
STJP001660

$834.98 - $2,577.83
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Host: HEK293
Note: STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human LILRB2/CD85d/ILT4-C-His-Avi protein was developed from hek293 and has a target region of C-His-Avi. For use in research applications.
Conjugation: Biotin
Formulation: Lyophilised from 0.2 µm filtered PBS solution pH7.4.
Dilution Range: Upon receipt centrifuge vial to ensure maximal product extraction, recommended: 20sec, 5K RPM
Storage Instruction: The lyophilized protein is stable for at least 1 year from date of receipt at-20°C.
Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg).
Gene Symbol: LILRB2
Gene ID: 10288
Uniprot ID: LIRB2_HUMAN
Immunogen Region: Gln22-His458
Immunogen: DNA sequence encoding Human LILRB2/CD85d/ILT4 including a C-His-Avi tag was expressed in HEK293 Cells. The recombinant protein was then biotinylated site specific using the AVItag biotinylation technology.
Post Translational Modifications Phosphorylated on tyrosine residues. Dephosphorylated by PTPN6.
Function Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles. Involved in the down-regulation of the immune response and the development of tolerance. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M) triggering differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.
Protein Name Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2
Lir-2
Leukocyte Immunoglobulin-Like Receptor 2
Cd85 Antigen-Like Family Member D
Immunoglobulin-Like Transcript 4
Ilt-4
Monocyte/Macrophage Immunoglobulin-Like Receptor 10
Mir-10
Cd Antigen Cd85d
Database Links Reactome: R-HSA-198933
Reactome: R-HSA-6798695
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2 protein
Lir-2 protein
Leukocyte Immunoglobulin-Like Receptor 2 protein
Cd85 Antigen-Like Family Member D protein
Immunoglobulin-Like Transcript 4 protein
Ilt-4 protein
Monocyte/Macrophage Immunoglobulin-Like Receptor 10 protein
Mir-10 protein
Cd Antigen Cd85d protein
LILRB2 protein
ILT4 protein
LIR2 protein
MIR10 protein

Information sourced from Uniprot.org

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