• Human LILRB1/ILT-2/CD85j protein (Recombinant) (C-His) (STJP001324)

Human LILRB1/ILT-2/CD85j protein (Recombinant) (C-His) (STJP001324)

SKU:
STJP001324

$97.88 - $301.73
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Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human LILRB1/ILT-2/CD85j-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Gene Symbol: LILRB1
Gene ID: 10859
Uniprot ID: LIRB1_HUMAN
Immunogen: Recombinant Human LILRB1/ILT-2/CD85j Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gly24-His458) of Human LILRB1 (Accession #NP_006660.4) fused with an 6×His tag at the C-terminus.
Post Translational Modifications Phosphorylated on tyrosine residues. Dephosphorylated by PTPN6.
Function Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of FCER1A signaling and serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide. Upon interaction with peptide-bound HLA-G-B2M complex, triggers secretion of growth-promoting factors by decidual NK cells. Reprograms B cells toward an immune suppressive phenotype.
Protein Name Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 1
Lir-1
Leukocyte Immunoglobulin-Like Receptor 1
Cd85 Antigen-Like Family Member J
Immunoglobulin-Like Transcript 2
Ilt-2
Monocyte/Macrophage Immunoglobulin-Like Receptor 7
Mir-7
Cd Antigen Cd85j
Database Links Reactome: R-HSA-198933
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Isoform 5: Secreted
Alternative Protein Names Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 1 protein
Lir-1 protein
Leukocyte Immunoglobulin-Like Receptor 1 protein
Cd85 Antigen-Like Family Member J protein
Immunoglobulin-Like Transcript 2 protein
Ilt-2 protein
Monocyte/Macrophage Immunoglobulin-Like Receptor 7 protein
Mir-7 protein
Cd Antigen Cd85j protein
LILRB1 protein
ILT2 protein
LIR1 protein
MIR7 protein

Information sourced from Uniprot.org

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