Human LILRB1/ILT-2/CD85j protein (Recombinant) (C-His) (STJP001324)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human LILRB1/ILT-2/CD85j Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gly24-His458) of Human LILRB1 (Accession #NP_006660.4) fused with an 6×His tag at the C-terminus.
General Information
| Short Description | Recombinant-Human LILRB1/ILT-2/CD85j-C-His protein was developed in hek293 cells using the region Gly24-His458. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 0.1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | LILRB1 |
| Gene ID | 10859 |
| Uniprot ID | LIRB1_HUMAN |
| Immunogen | Recombinant Human LILRB1/ILT-2/CD85j Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gly24-His458) of Human LILRB1 (Accession #NP_006660.4) fused with an 6×His tag at the C-terminus. |
| Immunogen Region | Gly24-His458 |
| Immunogen Sequence | GHLPKPTLWAEPGSVITQGS PVTLRCQGGQETQEYRLYRE KKTALWITRIPQELVKKGQF PIPSITWEHAGRYRCYYGSD TAGRSESSDPLELVVTGAYI KPTLSAQPSPVVNSGGNVIL QCDSQVAFDGFSLCKEGED EHPQCLNSQPHARGSSRAIF SVGPVSPSRRWWYRCYAYDS NSPYEWSLPSDLLELLVLGV SKKPSLSVQPGPIVAPEETL TLQCGSDAGYNRFVLYKDGE |
Additional Info
| Post Translational Modifications | Phosphorylated on tyrosine residues. Dephosphorylated by PTPN6. |
| Function | Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of FCER1A signaling and serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide. Upon interaction with peptide-bound HLA-G-B2M complex, triggers secretion of growth-promoting factors by decidual NK cells. Reprograms B cells toward an immune suppressive phenotype. |
| Protein Name | Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 1Lir-1Leukocyte Immunoglobulin-Like Receptor 1Cd85 Antigen-Like Family Member JImmunoglobulin-Like Transcript 2Ilt-2Monocyte/Macrophage Immunoglobulin-Like Receptor 7Mir-7Cd Antigen Cd85j |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 5: Secreted |
| Alternative Protein Names | Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 1 proteinLir-1 proteinLeukocyte Immunoglobulin-Like Receptor 1 proteinCd85 Antigen-Like Family Member J proteinImmunoglobulin-Like Transcript 2 proteinIlt-2 proteinMonocyte/Macrophage Immunoglobulin-Like Receptor 7 proteinMir-7 proteinCd Antigen Cd85j proteinLILRB1 proteinILT2 proteinLIR1 proteinMIR7 protein |
Information sourced from Uniprot.org