• Biotinylated Human LILRB1 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
  • The purity of Biotinylated Human LILRB1 is greater than 95% as determined by SEC-HPLC.
  • Immobilized Anti-LILRB1 Antibody, hFc Tag at 1 Mu g/ml (100 Mu l/well) on the plate. Dose response curve for Biotinylated Human LILRB1, His Tag with the EC50 of 0. 13 Mu g/ml determined by ELISA.

Human LILRB1/CD85j/ILT2 protein (Recombinant) (C-His-Avi) {Biotin} (STJP001602)

SKU:
STJP001602

$834.98 - $2,577.83
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Host: HEK293
Note: STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human LILRB1/CD85j/ILT2-C-His-Avi protein was developed from hek293 and has a target region of C-His-Avi. For use in research applications.
Conjugation: Biotin
Formulation: Lyophilised from 0.2 µm filtered PBS solution pH7.4.
Dilution Range: Upon receipt centrifuge vial to ensure maximal product extraction, recommended: 20sec, 5K RPM
Storage Instruction: The lyophilized protein is stable for at least 1 year from date of receipt at-20°C.
Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg).
Gene Symbol: LILRB1
Gene ID: 10859
Uniprot ID: LIRB1_HUMAN
Immunogen Region: Gly24-His458
Immunogen: DNA sequence encoding Human LILRB1/CD85j/ILT2 including a C-His-Avi tag was expressed in HEK293 Cells. The recombinant protein was then biotinylated site specific using the AVItag biotinylation technology.
Post Translational Modifications Phosphorylated on tyrosine residues. Dephosphorylated by PTPN6.
Function Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of FCER1A signaling and serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide. Upon interaction with peptide-bound HLA-G-B2M complex, triggers secretion of growth-promoting factors by decidual NK cells. Reprograms B cells toward an immune suppressive phenotype.
Protein Name Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 1
Lir-1
Leukocyte Immunoglobulin-Like Receptor 1
Cd85 Antigen-Like Family Member J
Immunoglobulin-Like Transcript 2
Ilt-2
Monocyte/Macrophage Immunoglobulin-Like Receptor 7
Mir-7
Cd Antigen Cd85j
Database Links Reactome: R-HSA-198933
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Isoform 5: Secreted
Alternative Protein Names Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 1 protein
Lir-1 protein
Leukocyte Immunoglobulin-Like Receptor 1 protein
Cd85 Antigen-Like Family Member J protein
Immunoglobulin-Like Transcript 2 protein
Ilt-2 protein
Monocyte/Macrophage Immunoglobulin-Like Receptor 7 protein
Mir-7 protein
Cd Antigen Cd85j protein
LILRB1 protein
ILT2 protein
LIR1 protein
MIR7 protein

Information sourced from Uniprot.org

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