Human KIN17 protein (Recombinant) (His-Tag) (STJP017905)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human KIN17-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in phosphate-Buffered Saline (pH 7.4) containing 20% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | KIN |
| Gene ID | 22944 |
| Uniprot ID | KIN17_HUMAN |
| Accession Number | NP_036443 |
| Immunogen | Human |
| Immunogen Region | 1-393aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Ubiquitously expressed in all tissues examined, with highest levels in skeletal muscle, heart and testis. Differentially expressed in non-tumorigenic and tumorigenic cell lines. Highly expressed in proliferating epithelial keratinocyte cells in vitro (at protein level). |
| Function | Involved in DNA replication and the cellular response to DNA damage. May participate in DNA replication factories and create a bridge between DNA replication and repair mediated by high molecular weight complexes. May play a role in illegitimate recombination and regulation of gene expression. May participate in mRNA processing. Binds, in vitro, to double-stranded DNA. Also shown to bind preferentially to curved DNA in vitro and in vivo. Binds via its C-terminal domain to RNA in vitro. |
| Protein Name | Dna/Rna-Binding Protein Kin17Binding To Curved DnaKin - Antigenic Determinant Of Reca Protein Homolog |
| Database Links | Reactome: R-HSA-8876725 |
| Cellular Localisation | NucleusCytoplasmDuring S PhaseStrongly Associated With The Nuclear MatrixAnd To Chromosomal Dna In The Presence Of Dna DamageAlso Shows Cytoplasmic Localization In Elongated Spermatids |
| Alternative Protein Names | Dna/Rna-Binding Protein Kin17 proteinBinding To Curved Dna proteinKin - Antigenic Determinant Of Reca Protein Homolog proteinKIN proteinBTCD proteinKIN17 protein |
Information sourced from Uniprot.org