Human KDM5D protein (Recombinant) (N-His) (STJP009709)

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STJP009709
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human KDM5D-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: KDM5D
Gene ID: 8284
Uniprot ID: KDM5D_HUMAN
Immunogen Region: Gly374-Asp611
Immunogen: Homo sapiens (Human)
Function Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May play a role in spermatogenesis. Involved in transcriptional repression of diverse metastasis-associated genes.in this function seems to cooperate with ZMYND8. Suppresses prostate cancer cell invasion. Regulates androgen receptor (AR) transcriptional activity by demethylating H3K4me3 active transcription marks.
Protein Name Lysine-Specific Demethylase 5d
Histocompatibility Y Antigen
H-Y
Histone Demethylase Jarid1d
Jumonji/Arid Domain-Containing Protein 1d
Protein Smcy
Histone H3-Trimethyl-L-Lysine(4 Demethylase 5d
Database Links Reactome: R-HSA-3214842
Cellular Localisation Nucleus
Alternative Protein Names Lysine-Specific Demethylase 5d protein
Histocompatibility Y Antigen protein
H-Y protein
Histone Demethylase Jarid1d protein
Jumonji/Arid Domain-Containing Protein 1d protein
Protein Smcy protein
Histone H3-Trimethyl-L-Lysine(4 Demethylase 5d protein
KDM5D protein
HY protein
HYA protein
JARID1D protein
KIAA0234 protein
SMCY protein

Information sourced from Uniprot.org

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