Human KDM5D protein (Recombinant) (N-His) (STJP009709)

Name: Human KDM5D protein (Recombinant) (N-His) (STJP009709)
SKU: STJP009709
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

HostE.coli

ImmunogenHomo sapiens (Human)

STJP009709

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Short Description	Recombinant-Human KDM5D-N-His protein was developed from e.coli for the region N-His. For use in research applications.
Applications	ELISA/Immunogen/SDS-PAGE/WB
Host	E.coli
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Dilution Range	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Formulation	Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.

Function	Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May play a role in spermatogenesis. Involved in transcriptional repression of diverse metastasis-associated genes.in this function seems to cooperate with ZMYND8. Suppresses prostate cancer cell invasion. Regulates androgen receptor (AR) transcriptional activity by demethylating H3K4me3 active transcription marks.
Protein Name	Lysine-Specific Demethylase 5d Histocompatibility Y Antigen H-Y Histone Demethylase Jarid1d Jumonji/Arid Domain-Containing Protein 1d Protein Smcy Histone H3-Trimethyl-L-Lysine(4 Demethylase 5d
Database Links	Reactome: R-HSA-3214842
Cellular Localisation	Nucleus
Alternative Protein Names	Lysine-Specific Demethylase 5d protein Histocompatibility Y Antigen protein H-Y protein Histone Demethylase Jarid1d protein Jumonji/Arid Domain-Containing Protein 1d protein Protein Smcy protein Histone H3-Trimethyl-L-Lysine(4 Demethylase 5d protein KDM5D protein HY protein HYA protein JARID1D protein KIAA0234 protein SMCY protein

Information sourced from Uniprot.org