Human Jagged1/JAG1/CD339 protein (Recombinant) (C-hFc) (STJP002673)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human Jagged1/JAG1/CD339 Protein is produced by Human cells expression system. The target protein is expressed with sequence (Trp896-Arg1065) of human Jagged-1/JAG1 (Accession #P78504) fused with an Fc tag at the C-terminus.
General Information
| Short Description | Recombinant-Human Jagged1/JAG1/CD339-C-hFc protein was developed in hek293 cells using the region Trp896-Arg1065. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.2 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | JAG1 |
| Gene ID | 182 |
| Uniprot ID | JAG1_HUMAN |
| Immunogen | Recombinant Human Jagged1/JAG1/CD339 Protein is produced by Human cells expression system. The target protein is expressed with sequence (Trp896-Arg1065) of human Jagged-1/JAG1 (Accession #P78504) fused with an Fc tag at the C-terminus. |
| Immunogen Region | Trp896-Arg1065 |
| Immunogen Sequence | WCGPRPCLLHKGHSECPSGQ SCIPILDDQCFVHPCTGVGE CRSSSLQPVKTKCTSDSYYQ DNCANITFTFNKEMMSPGLT TEHICSELRNLNILKNVSAE YSIYIACEPSPSANNEIHVA ISAEDIRDDGNPIKEITDKI IDLVSKRDGNSSLIAAVAEV RVQRRPLKNR |
Additional Info
| Function | Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. Enhances fibroblast growth factor-induced angiogenesis (in vitro). |
| Protein Name | Protein Jagged-1Jagged1Hj1Cd Antigen Cd339 |
| Database Links | Reactome: R-HSA-2122948Reactome: R-HSA-2644606Reactome: R-HSA-2660826Reactome: R-HSA-2691232Reactome: R-HSA-2894862Reactome: R-HSA-2979096Reactome: R-HSA-8941856Reactome: R-HSA-9013149Reactome: R-HSA-9013423Reactome: R-HSA-9013507Reactome: R-HSA-9013700Reactome: R-HSA-9831926 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane ProteinCell Membrane |
| Alternative Protein Names | Protein Jagged-1 proteinJagged1 proteinHj1 proteinCd Antigen Cd339 proteinJAG1 proteinJAGL1 protein |
Information sourced from Uniprot.org