Human ING2 protein (Recombinant) (His-Tag) (STJP018492)

Name: Human ING2 protein (Recombinant) (His-Tag) (STJP018492)
SKU: STJP018492
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

HostE.coli

ImmunogenHuman

STJP018492

Current Stock:

🚚 Free UK Delivery on orders over £150

Quantity:

Processing The item has been added

Enquire For Bulk Order

✓ 1-Year Performance Guarantee | SDS & Datasheet Included | Expert Tech Support | Covered by St John's Laboratory Guarantee

Short Description	Recombinant-Human ING2-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications	SDS-PAGE/Denatured
Host	E.coli
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Concentration	1 mg/mL
Formulation	Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol 0.4M urea
Storage Instruction	For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.

Gene Symbol	ING2
Gene ID	3622
Uniprot ID	ING2_HUMAN
Accession Number	NP_001555
Immunogen	Human
Immunogen Region	1-280aa
Immunogen Sequence	MGSSHHHHHH SSGLVPRGSH MGSMLGQQQQ QLYSSAALLT GERSRLLTCY VQDYLECVES LPHDMQRNVS VLRELDNKYQ ETLKEIDDVY EKYKKEDDLN QKKRLQQLLQ RALINSQELG DEKIQIVTQM LELVENRARQ MELHSQCFQD PAESERASDK AKMDSSQPER SSRRPRRQRT SESRDLCHMA NGIEDCDDQP PKEKKSKSAK KKKRSKAKQE REASPVEF

Tissue Specificity	Widely expressed. Higher expressed in colon-cancer tumor than in normal colon tissues.
Post Translational Modifications	Sumoylation enhances its association with SIN3A and is required for binding to some target gene promoters, this is the case for TMEM71.
Function	Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs).
Protein Name	Inhibitor Of Growth Protein 2 Inhibitor Of Growth 1-Like Protein Ing1lp P32 P33ing2
Database Links	Reactome: R-HSA-3899300 Reactome: R-HSA-6811555
Cellular Localisation	Nucleus Predominantly Nuclear Localized To Chromatin And Nuclear Matrix Upon Reduced Ptdins(5)P Levels Seems To Be Released From Chromatin And At Least Partially Translocated To The Cytoplasm
Alternative Protein Names	Inhibitor Of Growth Protein 2 protein Inhibitor Of Growth 1-Like Protein protein Ing1lp protein P32 protein P33ing2 protein ING2 protein ING1L protein

Information sourced from Uniprot.org