Human IL-23 (Interleukin-12 Subunit Beta) Antibody Pair (STJAP00434)
SPECIFICATIONS
HostMouse/Goat
ConjugationUnconjugated/Biotin
ImmunogenCapture immunogen: Recombinant Human IL-23 protien.Detection Immunogen: Recombinant Human IL-23 protien.
General Information
| Short Description | This IL-23 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA. |
| Applications | ELISA |
| Host | Mouse/Goat |
| Reactivity | Human |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated/Biotin |
| Concentration | 0.5 mg/mL |
| Purification | Capture Purification: Protein A or G.Detection Purification: Antigen Affinity. |
| Formulation | Capture Buffer: PBS with 0.04% Proclin 300; 50% glycerol; pH 7.5.Detection Buffer: PBS with 0.04% Proclin 300; 1% protective protein; 50% glycerol; pH 7.5. |
| Storage Instruction | Store at-20°C for the long term, and avoid freeze-thaw cycles. |
| Determination Method | Colormetric |
Target Information
| Gene Symbol | IL12B |
| Gene ID | 3593 |
| Uniprot ID | IL12B_HUMAN |
| Immunogen | Capture immunogen: Recombinant Human IL-23 protien.Detection Immunogen: Recombinant Human IL-23 protien. |
| Sample Type | Serum, plasma and other biological fluids |
Additional Info
| Function | Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. |
| Protein Name | Interleukin-12 Subunit BetaIl-12bCytotoxic Lymphocyte Maturation Factor 40 Kda SubunitClmf P40Il-12 Subunit P40Nk Cell Stimulatory Factor Chain 2Nksf2 |
| Database Links | Reactome: R-HSA-6783783Reactome: R-HSA-6785807Reactome: R-HSA-9020591Reactome: R-HSA-9020933 |
| Cellular Localisation | Secreted |
| Alternative Antibody Pair Names | Interleukin-12 Subunit Beta antibody pairIl-12b antibody pairCytotoxic Lymphocyte Maturation Factor 40 Kda Subunit antibody pairClmf P40 antibody pairIl-12 Subunit P40 antibody pairNk Cell Stimulatory Factor Chain 2 antibody pairNksf2 antibody pairIL12B antibody pairNKSF2 antibody pair |
Information sourced from Uniprot.org