Human IL-1R2 (Interleukin-1 Receptor Type 2) Antibody Pair (STJAP00379)
General Information
| Short Description | This IL-1R2 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA. |
| Applications | ELISA |
| Host | Rabbit/Mouse |
| Reactivity | Human |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated/Biotin |
| Concentration | 0.5 mg/mL |
| Purification | Capture Purification: Protein A or G.Detection Purification: Protein A or G. |
| Formulation | Capture Buffer: PBS with 0.04% Proclin 300; 50% glycerol; pH 7.5.Detection Buffer: PBS with 0.04% Proclin 300; 1% protective protein; 50% glycerol; pH 7.5. |
| Storage Instruction | Store at-20°C for the long term, and avoid freeze-thaw cycles. |
| Determination Method | Colormetric |
Target Information
| Gene Symbol | IL1R2 |
| Gene ID | 7850 |
| Uniprot ID | IL1R2_HUMAN |
| Immunogen | Capture immunogen: Recombinant Human IL-1R2 protien.Detection Immunogen: Recombinant Human IL-1R2 protien. |
| Sample Type | Serum, plasma and other biological fluids |
Additional Info
| Function | Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competitive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity.this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. |
| Protein Name | Interleukin-1 Receptor Type 2Il-1r-2Il-1rt-2Il-1rt2Cd121 Antigen-Like Family Member BCdw121bIl-1 Type Ii ReceptorInterleukin-1 Receptor BetaIl-1r-BetaInterleukin-1 Receptor Type IiCd Antigen Cd121b Cleaved Into - Interleukin-1 Receptor Type 2 - Membrane FormMil-1r2Mil-1rii - Interleukin-1 Receptor Type 2 - Soluble FormSil-1r2Sil-1rii |
| Database Links | Reactome: R-HSA-6783783Reactome: R-HSA-9020702 |
| Cellular Localisation | Isoform Short: SecretedIsoform Long: Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Pair Names | Interleukin-1 Receptor Type 2 antibody pairIl-1r-2 antibody pairIl-1rt-2 antibody pairIl-1rt2 antibody pairCd121 Antigen-Like Family Member B antibody pairCdw121b antibody pairIl-1 Type Ii Receptor antibody pairInterleukin-1 Receptor Beta antibody pairIl-1r-Beta antibody pairInterleukin-1 Receptor Type Ii antibody pairCd Antigen Cd121b Cleaved Into - Interleukin-1 Receptor Type 2 - Membrane Form antibody pairMil-1r2 antibody pairMil-1rii - Interleukin-1 Receptor Type 2 - Soluble Form antibody pairSil-1r2 antibody pairSil-1rii antibody pairIL1R2 antibody pairIL1RB antibody pair |
Information sourced from Uniprot.org
Citations
Product Review
Frequently Asked Questions
Common questions about Human IL-1R2 (Interleukin-1 Receptor Type 2) Antibody Pair (STJAP00379)
This antibody pair detects human IL-1R2 (Interleukin-1 Receptor Type 2), corresponding to UniProt entry P27930. Reactivity is confirmed for human samples only.
The capture antibody is unconjugated and the detection antibody is biotin-conjugated; both are supplied at 0.5 mg/mL. The capture antibody is formulated in PBS with 0.04% Proclin 300 and 50% glycerol at pH 7.5, while the detection antibody is formulated in PBS with 0.04% Proclin 300, 1% protective protein, and 50% glycerol at pH 7.5.
This antibody pair is validated for use in ELISA. No other assay formats are listed for this product.
Suitable sample types include serum, plasma, and other biological fluids. This product is for research use only and is not intended for diagnostic or therapeutic applications.
Both the capture and detection antibodies were raised against recombinant human IL-1R2 protein. The capture antibody is hosted in rabbit or mouse, and both antibodies were purified using Protein A or G.
Both components should be stored at -20°C for long-term storage. Freeze-thaw cycles should be avoided to maintain product integrity.
Orders typically arrive within 1 to 2 weeks, and often sooner depending on your location. If your timeline is critical, please contact us before ordering and we can advise on current lead times.
This product is shipped on gel ice packs to maintain integrity during transit. Priority shipping is used as standard to minimise time in transit.
A Certificate of Analysis (CoA) is provided with every order. If you do not receive one, please contact us and we will issue it promptly.