| Host: |
Rabbit/Mouse |
| Applications: |
ELISA |
| Reactivity: |
Human |
| Note: |
FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
| Short Description: |
This IL-1R2 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA. |
| Conjugation: |
Unconjugated/Biotin |
| Formulation: |
Capture Buffer: PBS with 0.04% Proclin 300; 50% glycerol; pH 7.5.Detection Buffer: PBS with 0.04% Proclin 300; 1% protective protein; 50% glycerol; pH 7.5. |
| Purification: |
Capture Purification: Protein A or G.Detection Purification: Protein A or G. |
| Concentration: |
0.5 mg/mL |
| Storage Instruction: |
Store at-20°C for long term, and avoid freeze-thaw cycles. |
| Determination Method: |
Colormetric |
| Gene Symbol: |
IL1R2 |
| Gene ID: |
7850 |
| Uniprot ID: |
IL1R2_HUMAN |
| Immunogen: |
Capture immunogen: Recombinant Human IL-1R2 protien.Detection Immunogen: Recombinant Human IL-1R2 protien. |
| Sample Type: |
Serum, plasma and other biological fluids |
| Function | Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competitive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity.this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. |
| Protein Name | Interleukin-1 Receptor Type 2Il-1r-2Il-1rt-2Il-1rt2Cd121 Antigen-Like Family Member BCdw121bIl-1 Type Ii ReceptorInterleukin-1 Receptor BetaIl-1r-BetaInterleukin-1 Receptor Type IiCd Antigen Cd121b Cleaved Into - Interleukin-1 Receptor Type 2 - Membrane FormMil-1r2Mil-1rii - Interleukin-1 Receptor Type 2 - Soluble FormSil-1r2Sil-1rii |
| Database Links | Reactome: R-HSA-6783783Reactome: R-HSA-9020702 |
| Cellular Localisation | Isoform Short: SecretedIsoform Long: Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Pair Names | Interleukin-1 Receptor Type 2 antibody pairIl-1r-2 antibody pairIl-1rt-2 antibody pairIl-1rt2 antibody pairCd121 Antigen-Like Family Member B antibody pairCdw121b antibody pairIl-1 Type Ii Receptor antibody pairInterleukin-1 Receptor Beta antibody pairIl-1r-Beta antibody pairInterleukin-1 Receptor Type Ii antibody pairCd Antigen Cd121b Cleaved Into - Interleukin-1 Receptor Type 2 - Membrane Form antibody pairMil-1r2 antibody pairMil-1rii - Interleukin-1 Receptor Type 2 - Soluble Form antibody pairSil-1r2 antibody pairSil-1rii antibody pairIL1R2 antibody pairIL1RB antibody pair |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
