Human IL-1R2/IL-1RT2/CD121b protein (Recombinant) (C-hFc & His) (STJP002602)

SKU:
STJP002602

£76.50 - £248.50
Current Stock:
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human IL-1R2/IL-1RT2/CD121b-C-hFc & His protein was developed from hek293 cells and has a target region of C-hFc & His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Immunoreactivity: Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human IL1RN at 10 Mu g/mL (100 Mu L/well) can bind Recombinant Human IL1R2 with a linear range of 7-30 ng/mL.
Gene Symbol: IL1R2
Gene ID: 7850
Uniprot ID: IL1R2_HUMAN
Immunogen Region: Met1-Glu343
Immunogen: Recombinant Human IL-1R2/IL-1RT2/CD121b Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Met1-Glu343) of human IL1R2 (Accession #NP_004624.1) fused with an Fc, 6×His tag at the C-terminus.
Function Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competitive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity.this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.
Protein Name Interleukin-1 Receptor Type 2
Il-1r-2
Il-1rt-2
Il-1rt2
Cd121 Antigen-Like Family Member B
Cdw121b
Il-1 Type Ii Receptor
Interleukin-1 Receptor Beta
Il-1r-Beta
Interleukin-1 Receptor Type Ii
Cd Antigen Cd121b Cleaved Into - Interleukin-1 Receptor Type 2 - Membrane Form
Mil-1r2
Mil-1rii - Interleukin-1 Receptor Type 2 - Soluble Form
Sil-1r2
Sil-1rii
Database Links Reactome: R-HSA-6783783
Reactome: R-HSA-9020702
Cellular Localisation Isoform Short: Secreted
Isoform Long: Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Interleukin-1 Receptor Type 2 protein
Il-1r-2 protein
Il-1rt-2 protein
Il-1rt2 protein
Cd121 Antigen-Like Family Member B protein
Cdw121b protein
Il-1 Type Ii Receptor protein
Interleukin-1 Receptor Beta protein
Il-1r-Beta protein
Interleukin-1 Receptor Type Ii protein
Cd Antigen Cd121b Cleaved Into - Interleukin-1 Receptor Type 2 - Membrane Form protein
Mil-1r2 protein
Mil-1rii - Interleukin-1 Receptor Type 2 - Soluble Form protein
Sil-1r2 protein
Sil-1rii protein
IL1R2 protein
IL1RB protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance