Human IL-7RA/CD127 protein (Recombinant) (C-hFc & His) (STJP002675)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human IL-7RA/CD127 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Glu21-Gly236) of human IL7R alpha (Accession #NP_002176.2) fused with an Fc, 6×His tag at the C-terminus.
General Information
| Short Description | Recombinant-Human IL-7RA/CD127-C-hFc & His protein was developed in hek293 cells using the region Glu21-Gly236. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity | Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human IL7 at 2 Mu g/mL (100 Mu L/well) can bind Recombinant Human IL7R alpha, the EC50 of Recombinant Human IL7R alpha is 48.44 ng/mL.|2.Measured by its binding |
| Determination Method | < 1.0 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | IL7R |
| Gene ID | 3575 |
| Uniprot ID | IL7RA_HUMAN |
| Immunogen | Recombinant Human IL-7RA/CD127 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Glu21-Gly236) of human IL7R alpha (Accession #NP_002176.2) fused with an Fc, 6×His tag at the C-terminus. |
| Immunogen Region | Glu21-Gly236 |
| Immunogen Sequence | ESGYAQNGDLEDAELDDYSF SCYSQLEVNGSQHSLTCAFE DPDVNITNLEFEICGALVEV KCLNFRKLQEIYFIETKKFL LIGKSNICVKVGEKSLTCKK IDLTTIVKPEAPFDLSVVYR EGANDFVVTFNTSHLQKKYV KVLMHDVAYRQEKDENKWTH VNLSSTKLTLLQRKLQPAAM YEIKVRSIPDHYFKGFWSEW SPSYYFRTPEINNSSG |
Additional Info
| Function | Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP). |
| Protein Name | Interleukin-7 Receptor Subunit AlphaIl-7 Receptor Subunit AlphaIl-7r Subunit AlphaIl-7r-AlphaIl-7raCdw127Cd Antigen Cd127 |
| Database Links | Reactome: R-HSA-1266695Reactome: R-HSA-8856825Reactome: R-HSA-8856828 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 3: Cell MembraneIsoform 4: Secreted |
| Alternative Protein Names | Interleukin-7 Receptor Subunit Alpha proteinIl-7 Receptor Subunit Alpha proteinIl-7r Subunit Alpha proteinIl-7r-Alpha proteinIl-7ra proteinCdw127 proteinCd Antigen Cd127 proteinIL7R protein |
Information sourced from Uniprot.org