Human IL-1R2/IL-1RT2/CD121b protein (Recombinant) (C-His) (STJP001107)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human IL-1R2/IL-1RT2/CD121b Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Met1-Glu343) of human IL1R2 (Accession #NP_004624.1) fused with a 6×His tag at the C-terminus.
General Information
| Short Description | Recombinant-Human IL-1R2/IL-1RT2/CD121b-C-His protein was developed in hek293 cells using the region Met1-Glu343. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity | Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human IL1R2 at 2 Mu g/mL (100 Mu L/well) can bind Human IL1RA with a linear range of 31.25-43.5 ng/mL. |
| Determination Method | < 0.1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | IL1R2 |
| Gene ID | 7850 |
| Uniprot ID | IL1R2_HUMAN |
| Immunogen | Recombinant Human IL-1R2/IL-1RT2/CD121b Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Met1-Glu343) of human IL1R2 (Accession #NP_004624.1) fused with a 6×His tag at the C-terminus. |
| Immunogen Region | Met1-Glu343 |
| Immunogen Sequence | MLRLYVLVMGVSAFTLQPAA HTGAARSCRFRGRHYKREFR LEGEPVALRCPQVPYWLWAS VSPRINLTWHKNDSARTVPG EEETRMWAQDGALWLLPALQ EDSGTYVCTTRNASYCDKMS IELRVFENTDAFLPFISYPQ ILTLSTSGVLVCPDLSEFTR DKTDVKIQWYKDSLLLDKDN EKFLSVRGTTHLLVHDVALE DAGYYRCVLTFAHEGQQYNI TRSIELRIKKKKEETIPVI |
Additional Info
| Function | Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competitive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity.this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. |
| Protein Name | Interleukin-1 Receptor Type 2Il-1r-2Il-1rt-2Il-1rt2Cd121 Antigen-Like Family Member BCdw121bIl-1 Type Ii ReceptorInterleukin-1 Receptor BetaIl-1r-BetaInterleukin-1 Receptor Type IiCd Antigen Cd121b Cleaved Into - Interleukin-1 Receptor Type 2 - Membrane FormMil-1r2Mil-1rii - Interleukin-1 Receptor Type 2 - Soluble FormSil-1r2Sil-1rii |
| Database Links | Reactome: R-HSA-6783783Reactome: R-HSA-9020702 |
| Cellular Localisation | Isoform Short: SecretedIsoform Long: Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Interleukin-1 Receptor Type 2 proteinIl-1r-2 proteinIl-1rt-2 proteinIl-1rt2 proteinCd121 Antigen-Like Family Member B proteinCdw121b proteinIl-1 Type Ii Receptor proteinInterleukin-1 Receptor Beta proteinIl-1r-Beta proteinInterleukin-1 Receptor Type Ii proteinCd Antigen Cd121b Cleaved Into - Interleukin-1 Receptor Type 2 - Membrane Form proteinMil-1r2 proteinMil-1rii - Interleukin-1 Receptor Type 2 - Soluble Form proteinSil-1r2 proteinSil-1rii proteinIL1R2 proteinIL1RB protein |
Information sourced from Uniprot.org