Human IL-18R1/CD218a protein (Recombinant) (C-hFc&His) (STJP000873)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human IL-18R1/CD218a Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Glu20-Arg329) of human IL18R1/CD218a (Accession #NP_003846.1) fused with an Fc, 6×His tag at the C-terminus.
General Information
| Short Description | Recombinant-Human IL-18R1/CD218a-C-hFc&His protein was developed in hek293 cells using the region Glu20-Arg329. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity | Measured by its binding ability in a functional ELISA.Immobilized IL18R1 Mouse mAb at 1 Mu g/mL (100 Mu L/well) can bind Human IL18R1 with a linear range of 0.03-1.06ng/ml. |
| Determination Method | < 0.1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | IL18R1 |
| Gene ID | 8809 |
| Uniprot ID | IL18R_HUMAN |
| Immunogen | Recombinant Human IL-18R1/CD218a Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Glu20-Arg329) of human IL18R1/CD218a (Accession #NP_003846.1) fused with an Fc, 6×His tag at the C-terminus. |
| Immunogen Region | Glu20-Arg329 |
| Immunogen Sequence | ESCTSRPHITVVEGEPFYLK HCSCSLAHEIETTTKSWYKS SGSQEHVELNPRSSSRIALH DCVLEFWPVELNDTGSYFFQ MKNYTQKWKLNVIRRNKHSC FTERQVTSKIVEVKKFFQIT CENSYYQTLVNSTSLYKNCK KLLLENNKNPTIKKNAEFED QGYYSCVHFLHHNGKLFNIT KTFNITIVEDRSNIVPVLLG PKLNHVAVELGKNVRLNCSA LLNEEDVIYWMFGEENGSD |
Additional Info
| Tissue Specificity | Highly expressed in leukocytes, spleen, lung. Also expressed, but at lower levels, in liver, small intestine, colon, prostate, thymus, placenta, and heart. Specifically coexpressed with IL18R1 in Th1 cells. |
| Post Translational Modifications | N-glycosylated. N-linked glycosyl chains contribute to ligand recognition and intra-receptor interactions required for formation of an active ternary receptor complex. |
| Function | Within the IL18 receptor complex, responsible for the binding of the pro-inflammatory cytokine IL18, but not IL1A nor IL1B. Involved in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells. Contributes to IL18-induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3. |
| Protein Name | Interleukin-18 Receptor 1Il-18r-1Il-18r1Cd218 Antigen-Like Family Member ACdw218aIl1 Receptor-Related ProteinIl-1rrpIl1r-RpInterleukin-18 Receptor AlphaIl-18r-AlphaIl-18ralphaCd Antigen Cd218a |
| Database Links | Reactome: R-HSA-9008059Reactome: R-HSA-9012546 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Interleukin-18 Receptor 1 proteinIl-18r-1 proteinIl-18r1 proteinCd218 Antigen-Like Family Member A proteinCdw218a proteinIl1 Receptor-Related Protein proteinIl-1rrp proteinIl1r-Rp proteinInterleukin-18 Receptor Alpha proteinIl-18r-Alpha proteinIl-18ralpha proteinCd Antigen Cd218a proteinIL18R1 proteinIL1RRP protein |
Information sourced from Uniprot.org