Host: |
HEK293 cells |
Reactivity: |
Human |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: |
Recombinant-Human IL-18R1/CD218a-C-hFc&His protein was developed from hek293 cells and has a target region of C-hFc&His. For use in research applications. |
Formulation: |
Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation. |
Immunoreactivity: |
Measured by its binding ability in a functional ELISA. Immobilized IL18R1 Mouse mAb at 1 Mu g/mL (100 Mu L/well) can bind Human IL18R1 with a linear range of 0.03-1.06ng/ml. |
Gene Symbol: |
IL18R1 |
Gene ID: |
8809 |
Uniprot ID: |
IL18R_HUMAN |
Immunogen: |
Recombinant Human IL-18R1/CD218a Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Glu20-Arg329) of human IL18R1/CD218a (Accession #NP_003846.1) fused with an Fc, 6×His tag at the C-terminus. |
Tissue Specificity | Highly expressed in leukocytes, spleen, lung. Also expressed, but at lower levels, in liver, small intestine, colon, prostate, thymus, placenta, and heart. Specifically coexpressed with IL18R1 in Th1 cells. |
Post Translational Modifications | N-glycosylated. N-linked glycosyl chains contribute to ligand recognition and intra-receptor interactions required for formation of an active ternary receptor complex. |
Function | Within the IL18 receptor complex, responsible for the binding of the pro-inflammatory cytokine IL18, but not IL1A nor IL1B. Involved in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells. Contributes to IL18-induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3. |
Protein Name | Interleukin-18 Receptor 1Il-18r-1Il-18r1Cd218 Antigen-Like Family Member ACdw218aIl1 Receptor-Related ProteinIl-1rrpIl1r-RpInterleukin-18 Receptor AlphaIl-18r-AlphaIl-18ralphaCd Antigen Cd218a |
Database Links | Reactome: R-HSA-9008059Reactome: R-HSA-9012546 |
Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
Alternative Protein Names | Interleukin-18 Receptor 1 proteinIl-18r-1 proteinIl-18r1 proteinCd218 Antigen-Like Family Member A proteinCdw218a proteinIl1 Receptor-Related Protein proteinIl-1rrp proteinIl1r-Rp proteinInterleukin-18 Receptor Alpha proteinIl-18r-Alpha proteinIl-18ralpha proteinCd Antigen Cd218a proteinIL18R1 proteinIL1RRP protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance