Human IL-18R1/CD218a protein (Recombinant) (C-hFc&His) (STJP000873)

Human IL-18R1/CD218a protein (Recombinant) (C-hFc&His) (STJP000873)

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STJP000873
£89.50 - £274.50
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Host: HEK293 cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Formulation: Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: < 0.1 EU/Mu g of the protein by LAL method.
Immunoreactivity: Measured by its binding ability in a functional ELISA.Immobilized IL18R1 Mouse mAb at 1 Mu g/mL (100 Mu L/well) can bind Human IL18R1 with a linear range of 0.03-1.06ng/ml.
Gene Symbol: IL18R1
Gene ID: 8809
Uniprot ID: IL18R_HUMAN
Immunogen: Recombinant Human IL-18R1/CD218a Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Glu20-Arg329) of human IL18R1/CD218a (Accession #NP_003846.1) fused with an Fc, 6×His tag at the C-terminus.
Immunogen Sequence: ESCTSRPHITVVEGEPFYLK HCSCSLAHEIETTTKSWYKS SGSQEHVELNPRSSSRIALH DCVLEFWPVELNDTGSYFFQ MKNYTQKWKLNVIRRNKHSC FTERQVTSKIVEVKKFFQIT CENSYYQTLVNSTSLYKNCK KLLLENNKNPTIKKNAEFED QGYYSCVHFLHHNGKLFNIT KTFNITIVEDRSNIVPVLLG PKLNHVAVELGKNVRLNCSA LLNEEDVIYWMFGEENGSD
Tissue Specificity Highly expressed in leukocytes, spleen, lung. Also expressed, but at lower levels, in liver, small intestine, colon, prostate, thymus, placenta, and heart. Specifically coexpressed with IL18R1 in Th1 cells.
Post Translational Modifications N-glycosylated. N-linked glycosyl chains contribute to ligand recognition and intra-receptor interactions required for formation of an active ternary receptor complex.
Function Within the IL18 receptor complex, responsible for the binding of the pro-inflammatory cytokine IL18, but not IL1A nor IL1B. Involved in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells. Contributes to IL18-induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3.
Protein Name Interleukin-18 Receptor 1
Il-18r-1
Il-18r1
Cd218 Antigen-Like Family Member A
Cdw218a
Il1 Receptor-Related Protein
Il-1rrp
Il1r-Rp
Interleukin-18 Receptor Alpha
Il-18r-Alpha
Il-18ralpha
Cd Antigen Cd218a
Database Links Reactome: R-HSA-9008059
Reactome: R-HSA-9012546
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Interleukin-18 Receptor 1 protein
Il-18r-1 protein
Il-18r1 protein
Cd218 Antigen-Like Family Member A protein
Cdw218a protein
Il1 Receptor-Related Protein protein
Il-1rrp protein
Il1r-Rp protein
Interleukin-18 Receptor Alpha protein
Il-18r-Alpha protein
Il-18ralpha protein
Cd Antigen Cd218a protein
IL18R1 protein
IL1RRP protein

Information sourced from Uniprot.org

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