Human IGFBP-2 (Insulin-Like Growth Factor-Binding Protein 2) Antibody Pair (STJAP00400)
SPECIFICATIONS
HostGoat/Goat
ConjugationUnconjugated/Biotin
ImmunogenCapture immunogen: Recombinant Human IGFBP-2 protien.Detection Immunogen: Recombinant Human IGFBP-2 protien.
General Information
| Short Description | This IGFBP-2 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA. |
| Applications | ELISA |
| Host | Goat/Goat |
| Reactivity | Human |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated/Biotin |
| Concentration | 0.5 mg/mL |
| Purification | Capture Purification: Antigen Affinity.Detection Purification: Antigen Affinity. |
| Formulation | Capture Buffer: PBS with 0.04% Proclin 300; 50% glycerol; pH 7.5.Detection Buffer: PBS with 0.04% Proclin 300; 1% protective protein; 50% glycerol; pH 7.5. |
| Storage Instruction | Store at-20°C for the long term, and avoid freeze-thaw cycles. |
| Determination Method | Colormetric |
Target Information
| Gene Symbol | IGFBP2 |
| Gene ID | 3485 |
| Uniprot ID | IBP2_HUMAN |
| Immunogen | Capture immunogen: Recombinant Human IGFBP-2 protien.Detection Immunogen: Recombinant Human IGFBP-2 protien. |
| Sample Type | Serum, plasma and other biological fluids |
Additional Info
| Function | Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type specific manner. Functions coordinately with receptor protein tyrosine phosphatase beta/PTPRB and the IGF1 receptor to regulate IGF1-mediated signaling by stimulating the phosphorylation of PTEN leading to its inactivation and AKT1 activation. Plays a positive role in cell migration via interaction with integrin alpha5/ITGA5 through an RGD motif. Additionally, interaction with ITGA5/ITGB1 enhances the adhesion of endothelial progenitor cells to endothelial cells. Upon mitochondrial damage, facilitates apoptosis with ITGA5 of podocytes, and then activates the phosphorylation of focal adhesion kinase (FAK)-mediated mitochondrial injury. |
| Protein Name | Insulin-Like Growth Factor-Binding Protein 2Ibp-2Igf-Binding Protein 2Igfbp-2 |
| Database Links | Reactome: R-HSA-381426 |
| Cellular Localisation | Secreted |
| Alternative Antibody Pair Names | Insulin-Like Growth Factor-Binding Protein 2 antibody pairIbp-2 antibody pairIgf-Binding Protein 2 antibody pairIgfbp-2 antibody pairIGFBP2 antibody pairBP2 antibody pairIBP2 antibody pair |
Information sourced from Uniprot.org