Human IGF-2 protein (Recombinant) (No-Tag) (STJP016974)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human IGF-2-No-Tag protein was developed from e.coli and has a target region of No-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.25 mg/mL |
| Formulation | Liquid in phosphate-buffered saline (pH 7.4) containing 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | IGF2 |
| Gene ID | 3481 |
| Uniprot ID | IGF2_HUMAN |
| Accession Number | NP_000603 |
| Immunogen | Human |
| Immunogen Region | 25-91aa |
| Immunogen Sequence | MAYRPSETLC GGELVDTLQF VCGDRGFYFS RPASRVSRRS RGIVEECCFR SCDLALLETY CATPAKSE |
Additional Info
| Tissue Specificity | Expressed in heart, placenta, lung, liver, muscle, kidney, tongue, limb, eye and pancreas. |
| Post Translational Modifications | O-glycosylated with core 1 or possibly core 8 glycans. Thr-96 is a minor glycosylation site compared to Thr-99. Proteolytically processed by PCSK4, proIGF2 is cleaved at Arg-128 and Arg-92 to generate big-IGF2 and mature IGF2. |
| Function | The insulin-like growth factors possess growth-promoting activity. Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF2 is influenced by placental lactogen. Also involved in tissue differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver (Probable). Acts as a ligand for integrin which is required for IGF2 signaling. Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation. Inhibits myoblast differentiation and modulates metabolism via increasing the mitochondrial respiration rate. Preptin undergoes glucose-mediated co-secretion with insulin, and acts as a physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3. |
| Protein Name | Insulin-Like Growth Factor 2Insulin-Like Growth Factor IiIgf-IiSomatomedin-AT3m-11-Derived Growth Factor Cleaved Into - Insulin-Like Growth Factor Ii Ala-25 Del - Preptin |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-2404192Reactome: R-HSA-2428928Reactome: R-HSA-2428933Reactome: R-HSA-381426 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Insulin-Like Growth Factor 2 proteinInsulin-Like Growth Factor Ii proteinIgf-Ii proteinSomatomedin-A proteinT3m-11-Derived Growth Factor Cleaved Into - Insulin-Like Growth Factor Ii Ala-25 Del - Preptin proteinIGF2 proteinIGF-2 proteinPP1446 protein |
Information sourced from Uniprot.org