Human IBSP/Sialoprotein II protein (Recombinant) (His-Tag) (STJP019542)
SPECIFICATIONS
HostHEK293 Cells
ImmunogenHuman
General Information
| Short Description | Recombinant-Human IBSP/Sialoprotein II-His-Tag protein was developed from hek293 cells and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE/Bioactivity |
| Host | HEK293 Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in phosphate-Buffered Saline (pH 7.4) containing 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
| Endotoxin | < 1 EU per 1ug of protein (determined by LAL method) |
| Immunoreactivity | Measured by the ability of the immobilized protein to support the adhesion of MCF7 human breast cancer cells. When cells are added to Human IBSP coated plates 3 ug/ml. This effect is more to 40%. |
Target Information
| Gene Symbol | IBSP |
| Gene ID | 3381 |
| Uniprot ID | SIAL_HUMAN |
| Accession Number | NP_004958.2 |
| Immunogen | Human |
| Immunogen Region | 17-317aa |
| Immunogen Sequence | FSMKNLHRRV KIEDSEENGV FKYRPRYYLY KHAYFYPHLK RFPVQGSSDS SEENGDDSSE EEEEEEETSN EGENNEESNE DEDSEAENTT LSATTLGYGE DATPGTGYTG LAAIQLPKKA GDITNKATKE KESDEEEEEE EEGNENEESE AEVDENEQGI NGTSTNSTEA ENGNGSSGGD NGEEGEEESV TGANAEDTTE TGRQGKGTSK TTTSPNGGFE PTTPPQVY |
Additional Info
| Tissue Specificity | Expressed in bone (at protein level). Expressed in trophoblast cells of placenta (at protein level). Expressed in brain. |
| Post Translational Modifications | N-glycosylated.glycans consist of sialylated and core-fucosylated bi-, tri- and tetraantennary chains. O-glycosylated at eight sites.mucin-type glycans contain Gal, GlcNAc, GalNAc and terminal NeuAc. |
| Function | Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes adhesion and migration of various cells via the alpha-V/beta-3 integrin receptor (ITGAV:ITGB3). |
| Protein Name | Integrin-Binding SialoproteinBone Sialoprotein 2Bone Sialoprotein IiBsp IiCell-Binding Sialoprotein |
| Database Links | Reactome: R-HSA-216083Reactome: R-HSA-3000178 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Integrin-Binding SialoproteinBone Sialoprotein 2 proteinBone Sialoprotein Ii proteinBsp Ii proteinCell-Binding SialoproteinIBSP proteinBNSP protein |
Information sourced from Uniprot.org