SDS-PAGE gel of recombinant human HOPX protein under reducing conditions stained with Coomassie blue

Human HOPX protein (Recombinant) (His-Tag) (STJP017748)

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STJP017748
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Short Description :Recombinant-Human HOPX-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:1 mg/mL
Formulation:Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol:HOPX
Gene ID:84525
Uniprot ID:HOP_HUMAN
Accession Number:NP_631957
Immunogen:Human
Immunogen Region:1-73aa
Immunogen Sequence:MGSSHHHHHH SSGLVPRGSH MGSHMSAETA SGPTEDQVEI LEYNFNKVDK HPDSTTLCLI AAEAGLSEEE TQKWFKQRLA KWRRSEGLPS ECRSVTD
Tissue Specificity Widely expressed. Expressed in the heart, brain, placenta, lung, skeletal and smooth muscles, uterus, urinary bladder, kidney and spleen. Down-regulated in some types of cancer such as lung cancer, choriocarcinoma, head and neck squamous cell carcinoma and oral squamous cell carcinoma.
Function Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy. May act as a tumor suppressor. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein refolding.
Protein Name Homeodomain-Only Protein
Lung Cancer-Associated Y Protein
Not Expressed In Choriocarcinoma Protein 1
Odd Homeobox Protein 1
Database Links Reactome: R-HSA-9725554
Cellular Localisation Nucleus
Cytoplasm
Alternative Protein Names Homeodomain-Only Protein protein
Lung Cancer-Associated Y Protein protein
Not Expressed In Choriocarcinoma Protein 1 protein
Odd Homeobox Protein 1 protein
HOPX protein
HOD protein
HOP protein
LAGY protein
NECC1 protein
OB1 protein

Information sourced from Uniprot.org

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