Human HOPX protein (Recombinant) (His-Tag) (STJP017748)

Name: Human HOPX protein (Recombinant) (His-Tag) (STJP017748)
SKU: STJP017748
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

HostE.coli

ImmunogenHuman

STJP017748

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Short Description	Recombinant-Human HOPX-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications	SDS-PAGE
Host	E.coli
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Concentration	1 mg/mL
Formulation	Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol
Storage Instruction	For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.

Gene Symbol	HOPX
Gene ID	84525
Uniprot ID	HOP_HUMAN
Accession Number	NP_631957
Immunogen	Human
Immunogen Region	1-73aa
Immunogen Sequence	MGSSHHHHHH SSGLVPRGSH MGSHMSAETA SGPTEDQVEI LEYNFNKVDK HPDSTTLCLI AAEAGLSEEE TQKWFKQRLA KWRRSEGLPS ECRSVTD

Tissue Specificity	Widely expressed. Expressed in the heart, brain, placenta, lung, skeletal and smooth muscles, uterus, urinary bladder, kidney and spleen. Down-regulated in some types of cancer such as lung cancer, choriocarcinoma, head and neck squamous cell carcinoma and oral squamous cell carcinoma.
Function	Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy. May act as a tumor suppressor. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein refolding.
Protein Name	Homeodomain-Only Protein Lung Cancer-Associated Y Protein Not Expressed In Choriocarcinoma Protein 1 Odd Homeobox Protein 1
Database Links	Reactome: R-HSA-9725554
Cellular Localisation	Nucleus Cytoplasm
Alternative Protein Names	Homeodomain-Only Protein protein Lung Cancer-Associated Y Protein protein Not Expressed In Choriocarcinoma Protein 1 protein Odd Homeobox Protein 1 protein HOPX protein HOD protein HOP protein LAGY protein NECC1 protein OB1 protein

Information sourced from Uniprot.org