Human HN1 protein (Recombinant) (His-Tag) (STJP018162)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human HN1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | JPT1 |
| Gene ID | 51155 |
| Uniprot ID | JUPI1_HUMAN |
| Accession Number | NP_057269 |
| Immunogen | Human |
| Immunogen Region | 1-154aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Expressed in testis, skeletal muscle, thymus, prostate, colon, peripheral blood cells, brain and placenta. |
| Function | Modulates negatively AKT-mediated GSK3B signaling. Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser-9' phosphorylation of GSK3B, which represses the function of the APC:CTNNB1:GSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions. Plays a role in the regulation of cell cycle and cell adhesion. Has an inhibitory role on AR-signaling pathway through the induction of receptor proteasomal degradation. |
| Protein Name | Jupiter Microtubule Associated Homolog 1Androgen-Regulated Protein 2Hematological And Neurological Expressed 1 Protein Cleaved Into - Jupiter Microtubule Associated Homolog 1 - N-Terminally Processed |
| Database Links | |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Protein Names | Jupiter Microtubule Associated Homolog 1 proteinAndrogen-Regulated Protein 2 proteinHematological And Neurological Expressed 1 Protein Cleaved Into - Jupiter Microtubule Associated Homolog 1 - N-Terminally Processed proteinJPT1 proteinARM2 proteinHN1 protein |
Information sourced from Uniprot.org