Human HJV protein (Recombinant) (N-His) (STJP005615)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human HJV-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | HJV |
| Gene ID | 148738 |
| Uniprot ID | RGMC_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met227-Asp400 |
Additional Info
| Post Translational Modifications | Autocatalytically cleaved at low pH.the two chains remain linked via two disulfide bonds. Also proteolytically processed by TMPRSS6, several fragments being released in the extracellular space.regulates HJV activity in BMP signaling and thefore iron homeostasis. |
| Function | Acts as a bone morphogenetic protein (BMP) coreceptor. Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis. |
| Protein Name | HemojuvelinHemochromatosis Type 2 ProteinHemojuvelin Bmp CoreceptorRgm Domain Family Member C |
| Database Links | Reactome: R-HSA-373752 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorAlso Released In The Extracellular Space |
| Alternative Protein Names | Hemojuvelin proteinHemochromatosis Type 2 Protein proteinHemojuvelin Bmp Coreceptor proteinRgm Domain Family Member C proteinHJV proteinHFE2 proteinRGMC protein |
Information sourced from Uniprot.org