Human HJV protein (Recombinant) (N-His) (STJP005615)

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STJP005615
€410.63 - €1,796.88
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human HJV-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: HJV
Gene ID: 148738
Uniprot ID: RGMC_HUMAN
Immunogen Region: Met227-Asp400
Immunogen: Homo sapiens (Human)
Post Translational Modifications Autocatalytically cleaved at low pH.the two chains remain linked via two disulfide bonds. Also proteolytically processed by TMPRSS6, several fragments being released in the extracellular space.regulates HJV activity in BMP signaling and thefore iron homeostasis.
Function Acts as a bone morphogenetic protein (BMP) coreceptor. Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis.
Protein Name Hemojuvelin
Hemochromatosis Type 2 Protein
Hemojuvelin Bmp Coreceptor
Rgm Domain Family Member C
Database Links Reactome: R-HSA-373752
Cellular Localisation Cell Membrane
Lipid-Anchor
Gpi-Anchor
Also Released In The Extracellular Space
Alternative Protein Names Hemojuvelin protein
Hemochromatosis Type 2 Protein protein
Hemojuvelin Bmp Coreceptor protein
Rgm Domain Family Member C protein
HJV protein
HFE2 protein
RGMC protein

Information sourced from Uniprot.org

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