Human HGFAC protein (Recombinant-Active) (N-His) (STJP012068)
SPECIFICATIONS
HostMammalian Cells
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Active-Human HGFAC-N-His protein was developed from mammalian cells and has a target region of N-His. For use in research applications. |
| Applications | ELISA/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | <0.1 EU/Mu g of the protein by the LAL method. |
| Immunoreactivity | Measured by its ability to cleave the fluorogenic peptide substrate, Mca-RPKPVE-Nval-WRK (Dnp)-NH2. The specific activity is >15 pmol/min/µg, as measured under the described conditions. |
Target Information
| Gene Symbol | HGFAC |
| Gene ID | 3083 |
| Uniprot ID | HGFA_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Gln36-Ser655 |
Additional Info
| Post Translational Modifications | The active form of HGFAC presents in the serum is derived from the COOH-terminal region of the precursor by the cleavage of bonds between Arg-372 and Val-373 and Arg-407 and Ile-408. |
| Function | Serine protease that hydrolyzes the inactive zymogen hepatocyte growth factor (HGFsc) to an activated disulfide-linked heterodimer, then initiating hepatocyte growth factor receptor signaling pathway. |
| Protein Name | Hepatocyte Growth Factor Activator Serine ProteaseHgf ActivatorHgfaHgfa Serine ProteaseSerine Protease Hgfac Cleaved Into - Hepatocyte Growth Factor Activator Short Chain - Hepatocyte Growth Factor Activator Long Chain |
| Database Links | Reactome: R-HSA-6806942 |
| Cellular Localisation | SecretedExists As An Inactive Zymogen In PlasmaExists As An Active Heterodimeric Form In Serum |
| Alternative Protein Names | Hepatocyte Growth Factor Activator Serine Protease proteinHgf Activator proteinHgfa proteinHgfa Serine Protease proteinSerine Protease Hgfac Cleaved Into - Hepatocyte Growth Factor Activator Short Chain - Hepatocyte Growth Factor Activator Long Chain proteinHGFAC protein |
Information sourced from Uniprot.org