Human HDGFL2 protein (Recombinant) (N-His-SUMO & C-Strep) (STJP010977)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human HDGFL2-N-His-SUMO & C-Strep protein was developed from e.coli for the region N-His-SUMO & C-Strep. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | HDGFL2 |
| Gene ID | 84717 |
| Uniprot ID | HDGR2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Asn87 |
Additional Info
| Function | Acts as an epigenetic regulator of myogenesis in cooperation with DPF3a (isoform 2 of DPF3/BAF45C). Associates with the BAF complex via its interaction with DPF3a and HDGFL2-DPF3a activate myogenic genes by increasing chromatin accessibility through recruitment of SMARCA4/BRG1/BAF190A (ATPase subunit of the BAF complex) to myogenic gene promoters. Promotes the repair of DNA double-strand breaks (DSBs) through the homologous recombination pathway by facilitating the recruitment of the DNA endonuclease RBBP8 to the DSBs. Preferentially binds to chromatin regions marked by H3K9me3, H3K27me3 and H3K36me2. Involved in cellular growth control, through the regulation of cyclin D1 expression. |
| Protein Name | Hepatoma-Derived Growth Factor-Related Protein 2Hdgf-Related Protein 2Hrp-2Hepatoma-Derived Growth Factor 2Hdgf-2 |
| Database Links | |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Protein Names | Hepatoma-Derived Growth Factor-Related Protein 2 proteinHdgf-Related Protein 2 proteinHrp-2 proteinHepatoma-Derived Growth Factor 2 proteinHdgf-2 proteinHDGFL2 proteinHDGF2 proteinHDGFRP2 proteinHRP2 proteinUNQ785 proteinPRO1604 protein |
Information sourced from Uniprot.org