Human HDGFL2 protein (Recombinant) (N-His-SUMO & C-Strep) (STJP010977)

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STJP010977
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human HDGFL2-N-His-SUMO & C-Strep protein was developed from e. coli and has a target region of N-His-SUMO & C-Strep. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: HDGFL2
Gene ID: 84717
Uniprot ID: HDGR2_HUMAN
Immunogen Region: Met1-Asn87
Immunogen: Homo sapiens (Human)
Function Acts as an epigenetic regulator of myogenesis in cooperation with DPF3a (isoform 2 of DPF3/BAF45C). Associates with the BAF complex via its interaction with DPF3a and HDGFL2-DPF3a activate myogenic genes by increasing chromatin accessibility through recruitment of SMARCA4/BRG1/BAF190A (ATPase subunit of the BAF complex) to myogenic gene promoters. Promotes the repair of DNA double-strand breaks (DSBs) through the homologous recombination pathway by facilitating the recruitment of the DNA endonuclease RBBP8 to the DSBs. Preferentially binds to chromatin regions marked by H3K9me3, H3K27me3 and H3K36me2. Involved in cellular growth control, through the regulation of cyclin D1 expression.
Protein Name Hepatoma-Derived Growth Factor-Related Protein 2
Hdgf-Related Protein 2
Hrp-2
Hepatoma-Derived Growth Factor 2
Hdgf-2
Cellular Localisation Nucleus
Cytoplasm
Alternative Protein Names Hepatoma-Derived Growth Factor-Related Protein 2 protein
Hdgf-Related Protein 2 protein
Hrp-2 protein
Hepatoma-Derived Growth Factor 2 protein
Hdgf-2 protein
HDGFL2 protein
HDGF2 protein
HDGFRP2 protein
HRP2 protein
UNQ785 protein
PRO1604 protein

Information sourced from Uniprot.org

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