Biotinylated Human GUCY2C on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Human GUCY2C/Guanylyl cyclase C protein (Recombinant) (C-His-Avi) {Biotin} (STJP001720)

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STJP001720
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Short Description :Recombinant-Human GUCY2C/Guanylyl cyclase C-C-His-Avi protein was developed from hek293 and has a target region of C-His-Avi. For use in research applications.
Host:HEK293
Note:STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Conjugation:Biotin
Dilution Range:Upon receipt centrifuge vial to ensure maximal product extraction, recommended: 20sec, 5K RPM
Formulation:Lyophilised from 0.2 µm filtered PBS solution pH7.4.
Storage Instruction:The lyophilized protein is stable for at least 1 year from date of receipt at-20°C.
Endotoxin:Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg).
Gene Symbol:GUCY2C
Gene ID:2984
Uniprot ID:GUC2C_HUMAN
Immunogen:DNA sequence encoding Human GUCY2C/Guanylyl cyclase C including a C-His-Avi tag was expressed in HEK293 Cells. The recombinant protein was then biotinylated site specific using the AVItag biotinylation technology.
Immunogen Region:Ser24-Gln430
Function Guanylyl cyclase that catalyzes synthesis of cyclic GMP (cGMP) from GTP. Receptor for the E.coli heat-stable enterotoxin.E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GUCY2C. Also activated by the endogenous peptides guanylin and uroguanylin.
Protein Name Guanylyl Cyclase C
Gc-C
Heat-Stable Enterotoxin Receptor
Sta Receptor
Hstar
Intestinal Guanylate Cyclase
Database Links Reactome: R-HSA-8935690
Reactome: R-HSA-8942233
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Endoplasmic Reticulum Membrane
The 145 Kda Plasma Membrane Form Of Gucy2c Contains Sialic Acid And Galactose Residues
While A Differencially Glycosylated 130 Kda Form Is A High Mannose Form That Is Resident In The Endoplasmic Reticulum And May Serve As The Precursor For The Cell Surface Form
Alternative Protein Names Guanylyl Cyclase C protein
Gc-C protein
Heat-Stable Enterotoxin Receptor protein
Sta Receptor protein
Hstar protein
Intestinal Guanylate Cyclase protein
GUCY2C protein
GUC2C protein
STAR protein

Information sourced from Uniprot.org

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