| Host: |
HEK293 cells |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Human Guanylyl cyclase C/GUCY2C-C-His&Avi protein was developed from hek293 cells and has a target region of C-His&Avi. For use in research applications. |
| Formulation: |
Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Endotoxin: |
Please contact us for more information. |
| Immunoreactivity: |
Measured by its binding ability in a functional ELISA. Immobilized Human GUCY2C at 1 Mu g/mL (100 Mu L/well) can bind GUCY2C Rabbit pAb with a linear range of 1-144 ng/mL. |
| Gene Symbol: |
GUCY2C |
| Gene ID: |
2984 |
| Uniprot ID: |
GUC2C_HUMAN |
| Immunogen: |
Recombinant Human Guanylyl cyclase C/GUCY2C Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser24-Gln430) of human GUCY2C/Guanylyl cyclase (Accession #NP_004954.2) fused with a 6×His, Avi tag at t |
| Function | Guanylyl cyclase that catalyzes synthesis of cyclic GMP (cGMP) from GTP. Receptor for the E.coli heat-stable enterotoxin.E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GUCY2C. Also activated by the endogenous peptides guanylin and uroguanylin. |
| Protein Name | Guanylyl Cyclase CGc-CHeat-Stable Enterotoxin ReceptorSta ReceptorHstarIntestinal Guanylate Cyclase |
| Database Links | Reactome: R-HSA-8935690Reactome: R-HSA-8942233 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinEndoplasmic Reticulum MembraneThe 145 Kda Plasma Membrane Form Of Gucy2c Contains Sialic Acid And Galactose ResiduesWhile A Differencially Glycosylated 130 Kda Form Is A High Mannose Form That Is Resident In The Endoplasmic Reticulum And May Serve As The Precursor For The Cell Surface Form |
| Alternative Protein Names | Guanylyl Cyclase C proteinGc-C proteinHeat-Stable Enterotoxin Receptor proteinSta Receptor proteinHstar proteinIntestinal Guanylate Cyclase proteinGUCY2C proteinGUC2C proteinSTAR protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
