Human Guanylyl cyclase C/GUCY2C protein (Recombinant) (C-His&Avi) (STJP001422)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human Guanylyl cyclase C/GUCY2C Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser24-Gln430) of human GUCY2C/Guanylyl cyclase (Accession #NP_004954.2) fused with a 6ΓHis, Avi tag at t
General Information
| Short Description | Recombinant-Human Guanylyl cyclase C/GUCY2C-C-His&Avi protein was developed in hek293 cells using the region Ser24-Gln430. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20Β°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity | Measured by its binding ability in a functional ELISA. Immobilized Human GUCY2C at 1 Mu g/mL (100 Mu L/well) can bind GUCY2C Rabbit pAb with a linear range of 1-144 ng/mL. |
| Determination Method | Please contact us for more information. |
Target Information
| Gene Symbol | GUCY2C |
| Gene ID | 2984 |
| Uniprot ID | GUC2C_HUMAN |
| Immunogen | Recombinant Human Guanylyl cyclase C/GUCY2C Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser24-Gln430) of human GUCY2C/Guanylyl cyclase (Accession #NP_004954.2) fused with a 6ΓHis, Avi tag at t |
| Immunogen Region | Ser24-Gln430 |
| Immunogen Sequence | SQVSQNCHNGSYEISVLMMG NSAFAEPLKNLEDAVNEGLE IVRGRLQNAGLNVTVNATFM YSDGLIHNSGDCRSSTCEGL DLLRKISNAQRMGCVLIGPS CTYSTFQMYLDTELSYPMIS AGSFGLSCDYKETLTRLMSP ARKLMYFLVNFWKTNDLPFK TYSWSTSYVYKNGTETEDCF WYLNALEASVSYFSHELGFK VVLRQDKEFQDILMDHNRKS NVIIMCGGPEFLYKLKGDR |
Additional Info
| Function | Guanylyl cyclase that catalyzes synthesis of cyclic GMP (cGMP) from GTP. Receptor for the E.coli heat-stable enterotoxin.E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GUCY2C. Also activated by the endogenous peptides guanylin and uroguanylin. |
| Protein Name | Guanylyl Cyclase CGc-CHeat-Stable Enterotoxin ReceptorSta ReceptorHstarIntestinal Guanylate Cyclase |
| Database Links | Reactome: R-HSA-8935690Reactome: R-HSA-8942233 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinEndoplasmic Reticulum MembraneThe 145 Kda Plasma Membrane Form Of Gucy2c Contains Sialic Acid And Galactose ResiduesWhile A Differencially Glycosylated 130 Kda Form Is A High Mannose Form That Is Resident In The Endoplasmic Reticulum And May Serve As The Precursor For The Cell Surface Form |
| Alternative Protein Names | Guanylyl Cyclase C proteinGc-C proteinHeat-Stable Enterotoxin Receptor proteinSta Receptor proteinHstar proteinIntestinal Guanylate Cyclase proteinGUCY2C proteinGUC2C proteinSTAR protein |
Information sourced from Uniprot.org