| Tissue Specificity | Detected in heart, brain, placenta, liver, skeletal muscle, kidney, testis, lung and pancreas. |
| Post Translational Modifications | Phosphorylated by GSK3B. |
| Function | A-kinase anchoring protein for GSK3B and PKA that regulates or facilitates their kinase activity towards their targets. The ternary complex enhances Wnt-induced signaling by facilitating the GSK3B- and PKA-induced phosphorylation of beta-catenin leading to beta-catenin degradation and stabilization respectively. Upon cAMP activation, the ternary complex contributes to neuroprotection against oxidative stress-induced apoptosis by facilitating the PKA-induced phosphorylation of DML1 and PKA-induced inactivation of GSK3B. During neurite outgrowth promotes neuron proliferation.while increases beta-catenin-induced transcriptional activity through GSK3B kinase activity inhibition, reduces N-cadherin level to promote cell cycle progression. |
| Protein Name | Gsk3b-Interacting ProteinGskipGsk3beta Interaction Protein |
| Database Links | |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Protein Names | Gsk3b-Interacting Protein proteinGskip proteinGsk3beta Interaction Protein proteinGSKIP proteinC14orf129 proteinHSPC210 protein |
Information sourced from Uniprot.org
