Human GSKIP protein (Recombinant) (His-Tag) (STJP017143)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human GSKIP-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% Glycerol, 50mM NaCl |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GSKIP |
| Gene ID | 51527 |
| Uniprot ID | GSKIP_HUMAN |
| Accession Number | NP_057556 |
| Immunogen | Human |
| Immunogen Region | 1-139aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH METDCNPMEL SSMSGFEEGS ELNGFEGTDM KDMRLEAEAV VNDVLFAVNN MFVSKSLRCA DDVAYINVET KERNRYCLEL TEAGLKVVGY AFDQVDDHLQ TPYHETVYSL LDTLSPAYRE AFGNALLQRL EALKRDGQS |
Additional Info
| Tissue Specificity | Detected in heart, brain, placenta, liver, skeletal muscle, kidney, testis, lung and pancreas. |
| Post Translational Modifications | Phosphorylated by GSK3B. |
| Function | A-kinase anchoring protein for GSK3B and PKA that regulates or facilitates their kinase activity towards their targets. The ternary complex enhances Wnt-induced signaling by facilitating the GSK3B- and PKA-induced phosphorylation of beta-catenin leading to beta-catenin degradation and stabilization respectively. Upon cAMP activation, the ternary complex contributes to neuroprotection against oxidative stress-induced apoptosis by facilitating the PKA-induced phosphorylation of DML1 and PKA-induced inactivation of GSK3B. During neurite outgrowth promotes neuron proliferation.while increases beta-catenin-induced transcriptional activity through GSK3B kinase activity inhibition, reduces N-cadherin level to promote cell cycle progression. |
| Protein Name | Gsk3b-Interacting ProteinGskipGsk3beta Interaction Protein |
| Database Links | |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Protein Names | Gsk3b-Interacting Protein proteinGskip proteinGsk3beta Interaction Protein proteinGSKIP proteinC14orf129 proteinHSPC210 protein |
Information sourced from Uniprot.org