Human GPRC5A protein (Recombinant) (N-GST) (STJP006408)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human GPRC5A-N-GST protein was developed from e.coli for the region N-GST. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | GPRC5A |
| Gene ID | 9052 |
| Uniprot ID | RAI3_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Thr269-Ser357 |
Additional Info
| Post Translational Modifications | Phosphorylated in two conserved double-tyrosine motifs, Tyr-317/Tyr-320 and Tyr-347/Tyr-350, by EGFR.leading to inactivation of the tumor suppressive function of GPRC5A in lung cancer cells. Tyr-317 and Tyr-320 are the preferred residues responsible for EGFR-mediated GPRC5A phosphorylation. |
| Function | Orphan receptor. Could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. This retinoic acid-inducible GPCR provide evidence for a possible interaction between retinoid and G-protein signaling pathways. Functions as a negative modulator of EGFR signaling. May act as a lung tumor suppressor. |
| Protein Name | Retinoic Acid-Induced Protein 3G-Protein Coupled Receptor Family C Group 5 Member APhorbol Ester Induced Gene 1Peig-1Retinoic Acid-Induced Gene 1 ProteinRaig-1 |
| Database Links | |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCytoplasmic Vesicle MembraneLocalized In Perinuclear VesiclesProbably Golgi-Associated Vesicles |
| Alternative Protein Names | Retinoic Acid-Induced Protein 3 proteinG-Protein Coupled Receptor Family C Group 5 Member A proteinPhorbol Ester Induced Gene 1 proteinPeig-1 proteinRetinoic Acid-Induced Gene 1 Protein proteinRaig-1 proteinGPRC5A proteinGPCR5A proteinRAI3 proteinRAIG1 protein |
Information sourced from Uniprot.org