Name: Human Glycophorin-A/GYPA/CD235a protein (Recombinant) (C-hFC) (STJP002451)
SKU: STJP002451
Availability: InStock

Human Glycophorin-A/GYPA/CD235a protein (Recombinant) (C-hFC) (STJP002451)

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STJP002451

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Host:	HEK293 cells
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Formulation:	Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method:	<0.01 EU/Mu g
Immunoreactivity:	Anti-GPA Antibody immobilized on CM5 Chip can bind Human GPA, hFc Tag with an affinity constant of 0.72 Mu M as determined in SPR assay (Biacore T200).

Gene Symbol:	GYPA
Gene ID:	2993
Uniprot ID:	GLPA_HUMAN
Immunogen Region:	Ser20-Glu91
Immunogen:	Recombinant Human Glycophorin-A Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser20-Glu91) of human Glycophorin-A (Accession #NP_002090.4) fused with a hFc tag at the C-terminus.
Immunogen Sequence:	SSTTGVAMHTSTSSSVTKSY ISSQTNDTHKRDTYAATPRA HEVSEISVRTVYPPEEETGE RVQLAHHFSEPE

Function	Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane. Glycophorin A is the major intrinsic membrane protein of the erythrocyte. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane, has MN blood group receptors. Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. May be involved in translocation of SLC4A1 to the plasma membrane. (Microbial infection) Appears to be a receptor for Hepatitis A virus (HAV). (Microbial infection) Receptor for P.falciparum erythrocyte-binding antigen 175 (EBA-175).binding of EBA-175 is dependent on sialic acid residues of the O-linked glycans.
Protein Name	Glycophorin-A Mn Sialoglycoprotein Pas-2 Sialoglycoprotein Alpha Cd Antigen Cd235a
Database Links	Reactome: R-HSA-202733
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein Appears To Be Colocalized With Slc4a1
Alternative Protein Names	Glycophorin-A protein Mn Sialoglycoprotein Pas-2 protein Sialoglycoprotein Alpha protein Cd Antigen Cd235a protein GYPA protein GPA protein MNS protein

Information sourced from Uniprot.org

Model	Name	Host
STJP002856	Human CD9 protein (Recombinant) (C-hFC) (STJP002856)	HEK293 cells
STJP001977	Human NBL1 protein (Recombinant) (C-hFc) (STJP001977)	HEK293 cells
STJP002461	Human CD7 protein (Recombinant) (C-hFc) (STJP002461)	HEK293 cells

Human Glycophorin-A/GYPA/CD235a protein (Recombinant) (C-hFC) (STJP002451)